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Volume 32, Issue 1

Original Article

Distribution and Antimicrobial Sensitivity of Microorganisms Isolated From Febrile Neutropenic Patients: Results of A Six-Year Observation

Burcu Deniz Yayla
Affiliations
  • Muş Malazgirt Devlet Hastanesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, Muş, Türkiye
,
Emel Azak
Affiliations
  • Kocaeli Üniversitesi, Tıp Fakültesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Kocaeli, Türkiye
,
Birsen Mutlu
Affiliations
  • Kocaeli Üniversitesi, Tıp Fakültesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Kocaeli, Türkiye
,
Devrim Dündar
Affiliations
  • Kocaeli Üniversitesi, Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Kocaeli, Türkiye
  • antibiotic susceptibility
  • culture
  • febrile neutropenia

Abstract

Objective: In this study, we aimed to investigate the distribution of microorganisms isolated from febrile neutropenic patients in the adult hematology clinic and their antimicrobial susceptibilities for six years.

Methods: The results of culture samples taken during 598 febrile episodes of 556 neutropenic patients admitted to the adult hematology clinic between January 2010 and December 2015 were retrospectively evaluated. Bactec™ 9120 (Becton Dickinson, Sparks, MD, USA) automated system for blood cultures from patients. Conventional diagnostic methods for identification and antibiogram, and VITEK® 2 (bioMérieux, Marcy l’Etoile, France) automated system was used if necessary.

Results: During the six-year study period, 556 neutropenic patients were evaluated in 299 (53.7%) male patients. As the underlying diseases, 233 (42%) acute myeloid leukemia, 122 (22%) acute lymphoblastic leukemia, and 112 (20%) lymphoma were mostly seen. Gram-negative bacteria were the most frequent cause and their distribution were Escherichia coli, Klebsiella, Acinetobacter and Pseudomonas in order of frequency. Extended-spectrum β-lactamase positivity in E. coli was 51%, while in Klebsiella spp. it was 55%. Coagulase-negative staphylococci (21%), E. coli (19%) and Klebsiella spp. (16%) were the most frequently isolated microorganisms. Enterococci were the most frequently isolated Gram-positive bacteria in 2012, exceptionally.

Conclusions: In febrile neutropenia, a problem with frequent occurrence and fatality potential, we should closely monitor the resistance surveillance in organisms isolated, and review the antibacterial drugs frequently used for success of empirical therapy protocols. Klimik Dergisi 2019; 32(1): 71-7.

Cite this article as: Yayla BD, Azak E, Mutlu B, Dündar D. [Distribution and antimicrobial sensitivity of microorganisms isolated from febrile neutropenic patients: results of a six-year observation]. Klimik Derg. 2019; 32(1): 71-7. Turkish.

  • 71-77
  • 10.5152/kd.2019.16
  • July 23, 2019
  • 3132
  • 719
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  • This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License. CC BY-NC
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