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Volume 35, Issue 2

Review

Pseudomonas aerugionosa Resistome and Epidemic High-Risk Clones

Öznur Gürpınar
Affiliations
  • Hacettepe Üniversitesi Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Ankara, Türkiye
https://orcid.org/0000-0002-2855-2961
,
Özgen Köseoğlu-Eser
Affiliations
  • Hacettepe Üniversitesi Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Ankara, Türkiye
https://orcid.org/0000-0002-2552-7971
  • epidemic high-risk clones
  • evolution
  • mutation
  • Pseudomonas aeruginosa
  • resistome

Abstract

The worldwide spread of multidrug-resistant /extensively drug-resistant Pseudomonas aeruginosa high-risk clones is a global health threat. P. aeruginosa has an evident capacity for developing antimicrobial resistance to nearly all available antipseudomonal agents through the selection of chromosomal mutations. Analysis of whole genome sequencing mutational resistomes has proven to be useful for understanding the evolutionary dynamics of antibiotic resistance mechanisms and characterization of widespread epidemic high-risk clones. The analysis of the P. aeruginosa resistome should permit to design therapeutic strategies and to monitor the efficacy of administered antibiotic treatments. In this review, the main genes and mutations which shape the P. aeruginosa resistome and the epidemic high-risk clones of P. aeruginosa are reviewed.

  • 55-63
  • Özgen Köseoğlu-Eser
  • [email protected]
  • 10.36519/kd.2022.4002
  • September 1, 2021
  • January 29, 2022
  • June 27, 2022

  • Gürpınar Ö, Köseoğlu-Eser Ö. [Pseudomonas aeruginosa resistome and epidemic high-risk clones]. Klimik Derg. 2022;35(2):55-63. Turkish.
  • 372
  • 187
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  • This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License. CC BY-NC
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