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Volume 22, Issue 3

Original Article

Evaluation of Total Oxidative Level and Total Antioxidant Capacity in Cases with Chronic Viral Hepatitis

Fatma Sırmatel
Affiliations
  • Abant İzzet Baysal Üniversitesi, Tıp Fakültesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Bolu, Türkiye
,
Fazilet Duygu
Affiliations
  • Harran Üniversitesi, Tıp Fakültesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Şanlıurfa, Türkiye
,
Hakim Çelik
Affiliations
  • Harran Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Şanlıurfa, Türkiye
,
Şahabettin Selek
Affiliations
  • Harran Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Şanlıurfa, Türkiye
,
Öcal Sırmatel
Affiliations
  • Abant İzzet Baysal Üniversitesi, İzzet Baysal Tıp Fakültesi, Radyodiyagnostik Anabilim Dalı, Bolu, Türkiye
,
Bensu Gürsoy
Affiliations
  • Harran Üniversitesi, Tıp Fakültesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Şanlıurfa, Türkiye
,
Fatma Nur Eriş
Affiliations
  • Abant İzzet Baysal Üniversitesi, İzzet Baysal Tıp Fakültesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Bolu, Türkiye
  • chronic viral hepatitis
  • Total antioxidant capacity
  • total oxidative level

Abstract

Objective: Oxidative stress is described as an instability between production of free radicals from cells and antioxidant defence of the body. The aim of the study was to investigate the correlation of total antioxidant capacity (TAC) and total oxidative level (TOL) with the severity of the disease and reliability of these parameters in the follow up of response to treatment in cases with chronic viral hepatitis (CVH).

Methods: Between January 2004-March 2006, 73 cases with CVH were included in the study. The ages of the patients ranged from 15 to 70 years. Diagnosis of CVH was confirmed by clinical serological, and biochemical markers. The cases were divided into two groups: Group 1 as HBsAg-positive or anti-HCV-positive but HBV DNA or HCV RNA-negative and Group 2 as proven CVH. TAC, lipid hydroperoxide (LOOH), and TOL of the sera were studied according to Erel method, and statistically evaluated by χ2 test in all the cases. 

Results: TAC, LOOH and TOL were found statistically significantly different between two groups. Average values of TAC were 1.8±0.5 mmol Trolox-Eqv./L and 1.0±0.15 mmol Trolox-Eqv./L in Group 1 and Group 2 ( p=0.0001) respectively. Average values of LOOH were 5.3±2.8 µmol H202 in Group 1 and 10.6±10.1 µmol H202 in Group 2 (p=0.002). Average values of TOL were 10.2±5.9 µmol H2O2 Eqv./L in Group 1 and 18.5±16.6 µmol H2O2 Eqv./L in Group 2 (p=0.004).

Conclusions: TAC was found higher, and TOL and LOOH were found lower in Group 1 than Group 2. The evaluation of plasma TAC, TOS ve LOOH levels may be important activation markers for the follow up of CVH. 

  • 92-96
  • July 23, 2019
  • 1818
  • 630
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  • This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License. CC BY-NC
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