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Volume 38, Issue 3

Case Report

Mediterranean Spotted Fever with Severe Course Detected in Alanya: A Case Report

Haluk Erdoğan
Affiliations
  • Alanya Alaaddin Keykubat Üniversitesi Tıp Fakültesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Antalya, Türkiye
https://orcid.org/0000-0002-9033-4236
,
Betül Arslan-Akdağ
Affiliations
  • Alanya Alaaddin Keykubat Üniversitesi Tıp Fakültesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Antalya, Türkiye
https://orcid.org/0009-0002-0672-0829
,
Mustafa Güldal
Affiliations
  • Alanya Alaaddin Keykubat Üniversitesi Tıp Fakültesi, İç Hastalıkları Ana Bilim Dalı, Antalya, Türkiye
https://orcid.org/0009-0006-6883-4337
,
Aşkın Erdoğan
Affiliations
  • Alanya Alaaddin Keykubat Üniversitesi Tıp Fakültesi, İç Hastalıkları Ana Bilim Dalı, Gastroenteroloji Ünitesi, Antalya, Türkiye
https://orcid.org/0000-0002-0203-8075
  • Mediterranean spotted fever
  • Rhipicephalus sanguineus
  • Rickettsia conorii

Abstract

A 40-year-old female patient was admitted to the emergency department with high-grade fever, headache, generalized joint pain, and a history of tick attachment. On physical examination, body temperature was 39.5ºC, with diffuse maculopapular rash and conjunctival hyperemia. Laboratory findings include mild anemia, profound lymphopenia, severe thrombocytopenia, severe hyponatremia, markedly elevated procalcitonin and C-reactive protein (CRP) levels, abnormal liver function tests, and severe hypocalcemia. Indirect fluorescent antibody (IFA) testing revealed positivity for both immunoglobulin M (IgM) and immunoglobulin G (IgG) against Rickettsia conorii. The patient responded well to doxycycline therapy and was discharged in good condition. To the best of our knowledge, this is the first reported case of Mediterranean spotted fever identified in the Mediterranean region of Türkiye.

Show References

References

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  8. Uzunlulu M, Eken E, Gönenç İ, Kaya S, Selvi E, Arslan F. A case of Mediterranean spotted fever mimicking severe sepsis. J Vector Borne Dis. 2022;59(3):298-301. [CrossRef]
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  10. Botelho-Nevers E, Rovery C, Richet H, Raoult D. Analysis of risk factors for malignant Mediterranean spotted fever indicates that fluoroquinolone treatment has a deleterious effect. J Antimicrob Chemother. 2011;66(8):1821-30. [CrossRef] 
  • 193-7
  • Haluk Erdoğan
  • [email protected]
  • 10.36519/kd.2025.5083
  • July 26, 2024
  • June 17, 2025
  • September 27, 2025

  • Erdoğan H, Arslan-Akdağ B, Güldal M, Erdoğan A. [Mediterranean spotted fever with severe course detected in Alanya: A case report]. Klimik Derg. 2025;38(3):193-7. Turkish.
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