Doripenem, bir\u00e7ok diren\u00e7li patojene kar\u015f\u0131 en etkin antibiyotik s\u0131n\u0131f\u0131 olan karbapenemlerin en yeni \u00fcyesidir. Bu derlemede doripenemin antimikrobik, farmakolojik ve klinik \u00f6zellikleri g\u00f6zden ge\u00e7irilmektedir. Doripenemin etkinlik spektrumu meropenem ve imipeneminkine benzer. Karbapenemlerin kar\u015f\u0131la\u015ft\u0131rmal\u0131 etkinli\u011finin ara\u015ft\u0131r\u0131ld\u0131\u011f\u0131 \u00e7ok merkezli \u00a0COMPACT \u00e7al\u0131\u015fmas\u0131n\u0131n T\u00fcrkiye verisine g\u00f6re doripenem, MIC 2 \u00b5g\/ml d\u00fczeyinde Pseudomonas aeruginosa izolatlar\u0131ndan %64\u2019\u00fcn\u00fc inhibe ederken; meropenem %56.2\u2019sini, imipenem ise %48.2\u2019sini inhibe etmi\u015ftir. Doripenem, imipenem ve meropenemden farkl\u0131 olarak oda s\u0131cakl\u0131\u011f\u0131nda 12 saat stabil kal\u0131r ve 4 saatlik uzat\u0131lm\u0131\u015f inf\u00fczyon uygulamas\u0131 g\u00fcvenle yap\u0131labilir. Bu uygulamayla, doripenem konsantrasyonu, \u00a0duyarl\u0131l\u0131\u011f\u0131 azalm\u0131\u015f patojenlerin MIC\u2019lerinin \u00fczerinde daha uzun s\u00fcre kalm\u0131\u015f olur. Hayvan modellerindeki \u00e7al\u0131\u015fmalara g\u00f6re doripenemin epileptojenik potansiyeli imipeneminkinden d\u00fc\u015f\u00fckt\u00fcr. Doripenem duyarl\u0131 patojenlerin neden oldu\u011fu komplike intraabdominal infeksiyonlar, komplike \u00fcriner sistem infeksiyonlar\u0131, hastane k\u00f6kenli pn\u00f6moni ve ventilat\u00f6rle ili\u015fkili pn\u00f6moni tedavisinde ruhsatland\u0131r\u0131lm\u0131\u015ft\u0131r.<\/p>\n","protected":false},"excerpt":{"rendered":"
\u00d6zet Doripenem, bir\u00e7ok diren\u00e7li patojene kar\u015f\u0131 en etkin antibiyotik s\u0131n\u0131f\u0131 olan karbapenemlerin en yeni \u00fcyesidir. Bu derlemede doripenemin antimikrobik, farmakolojik ve klinik \u00f6zellikleri g\u00f6zden ge\u00e7irilmektedir. Doripenemin etkinlik spektrumu meropenem ve imipeneminkine benzer. Karbapenemlerin kar\u015f\u0131la\u015ft\u0131rmal\u0131 etkinli\u011finin ara\u015ft\u0131r\u0131ld\u0131\u011f\u0131 \u00e7ok merkezli \u00a0COMPACT \u00e7al\u0131\u015fmas\u0131n\u0131n T\u00fcrkiye verisine g\u00f6re doripenem, MIC 2 \u00b5g\/ml d\u00fczeyinde Pseudomonas aeruginosa izolatlar\u0131ndan %64\u2019\u00fcn\u00fc inhibe ederken; meropenem […]<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5127],"tags":[3947,3948,3064],"class_list":["post-16715","post","type-post","status-publish","format-standard","hentry","category-derleme","tag-doripenem","tag-karbapenem","tag-pseudomonas-aeruginosa"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts\/16715","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/comments?post=16715"}],"version-history":[{"count":0,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts\/16715\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/media?parent=16715"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/categories?post=16715"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/tags?post=16715"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}