{"id":16175,"date":"2021-01-05T01:24:46","date_gmt":"2021-01-04T22:24:46","guid":{"rendered":"https:\/\/www.klimikdergisi.org\/\/2021\/01\/05\/alanin-aminotransferaz-duzeyi-normal-kronik-hepatit-c-infeksiyonlu-hastalarin-karaciger-histolojileri\/"},"modified":"2021-01-05T01:24:46","modified_gmt":"2021-01-04T22:24:46","slug":"alanin-aminotransferaz-duzeyi-normal-kronik-hepatit-c-infeksiyonlu-hastalarin-karaciger-histolojileri","status":"publish","type":"post","link":"https:\/\/www.klimikdergisi.org\/tr\/2021\/01\/05\/alanin-aminotransferaz-duzeyi-normal-kronik-hepatit-c-infeksiyonlu-hastalarin-karaciger-histolojileri\/","title":{"rendered":"Alanin Aminotransferaz D\u00fczeyi Normal Kronik Hepatit C \u0130nfeksiyonlu Hastalar\u0131n Karaci\u011fer Histolojileri"},"content":{"rendered":"<h1>\u00d6zet<\/h1>\n<p> <strong>Ama\u00e7<\/strong>: Bu \u00e7al\u0131\u015fmada alanin aminotransferaz (ALT) d\u00fczeyi normal kronik hepatit C (KHC)\u2019li hastalarda karaci\u011ferdeki histolojik de\u011fi\u015fikliklerin de\u011ferlendirilmesi ama\u00e7lanm\u0131\u015ft\u0131r.\u00a0<\/p>\n<p> <strong>Y\u00f6ntemler<\/strong>: \u00c7ok merkezli retrospektif \u00e7al\u0131\u015fmam\u0131zda &gt;16 ya\u015f, ALT d\u00fczeyi normal, KHC\u2019li 72 hasta de\u011ferlendirildi. ALT\u2019nin en az 6 ay s\u00fcresince ve en az birer ay arayla 2 veya 3 kez normal s\u0131n\u0131rlar i\u00e7inde olmas\u0131 \u201cnormal ALT d\u00fczeyi\u201d kabul edildi. Demografik veriler, tan\u0131 konulan y\u0131l, 6 ay i\u00e7indeki en az 2 ALT de\u011feri, hepatit g\u00f6stergeleri, hepatit C virusu (HCV) RNA ve karaci\u011fer biyopsisi sonu\u00e7lar\u0131 kaydedildi. Hepatit g\u00f6stergeleri farkl\u0131 kitlerle test edildi. HCV RNA, \u00f6l\u00e7\u00fcm aral\u0131\u011f\u0131 ve duyarl\u0131l\u0131\u011f\u0131 farkl\u0131 polimeraz zincir reaksiyonu kitleriyle \u00e7al\u0131\u015f\u0131ld\u0131. Biyopsi preparatlar\u0131 ayn\u0131 patologca tekrar de\u011ferlendirildi.\u00a0<\/p>\n<p> <strong>Bulgular<\/strong>: Hastalar\u0131n ya\u015f ortalamas\u0131 44\u00b113 y\u0131ld\u0131 ve %61.1\u2019i kad\u0131nd\u0131. HCV RNA de\u011ferleri 1.53&#215;102-1.13&#215;108 \u0130\u00dc\/ml aras\u0131ndayd\u0131. ALT de\u011ferleri ortalamas\u0131 30.3\u00b19.6 \u0130\u00dc\/lt bulundu. Histopatolojik olarak ortalama nekroinflamasyon derecesi 4.67\u00b11.96 ve ortalama fibroz evresi 1.03\u00b11.13 idi. Biyopsilerin %48.6\u2019s\u0131nda minimal aktivite, %45.8\u2019inde hafif aktivite ve %2.8\u2019inde orta aktivite saptand\u0131. Portal-periportal fibroz oran\u0131 %51.4, k\u00f6pr\u00fcle\u015fen fibroz oran\u0131 %6.9 ve inkomplet-komplet siroz oran\u0131 %1.4 idi.<\/p>\n<p> <strong>Sonu\u00e7lar<\/strong>: KHC\u2019li hastalarda ALT d\u00fczeyleri hastal\u0131\u011f\u0131n aktivitesini belirlemede zay\u0131f bir g\u00f6stergedir. Tedavi indikasyonu olan hastalar karaci\u011fer biyopsisi a\u00e7\u0131s\u0131ndan de\u011ferlendirilmelidir.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u00d6zet Ama\u00e7: Bu \u00e7al\u0131\u015fmada alanin aminotransferaz (ALT) d\u00fczeyi normal kronik hepatit C (KHC)\u2019li hastalarda karaci\u011ferdeki histolojik de\u011fi\u015fikliklerin de\u011ferlendirilmesi ama\u00e7lanm\u0131\u015ft\u0131r.\u00a0 Y\u00f6ntemler: \u00c7ok merkezli retrospektif \u00e7al\u0131\u015fmam\u0131zda &gt;16 ya\u015f, ALT d\u00fczeyi normal, KHC\u2019li 72 hasta de\u011ferlendirildi. ALT\u2019nin en az 6 ay s\u00fcresince ve en az birer ay arayla 2 veya 3 kez normal s\u0131n\u0131rlar i\u00e7inde olmas\u0131 \u201cnormal ALT [&hellip;]<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5129],"tags":[4169,2580,4171,4173],"class_list":["post-16175","post","type-post","status-publish","format-standard","hentry","category-ozgun-arastirma","tag-alanin-transaminaz","tag-hepatit-c-virusu","tag-histoloji","tag-kronik-karaciger-hastaligi"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts\/16175","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/comments?post=16175"}],"version-history":[{"count":0,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts\/16175\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/media?parent=16175"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/categories?post=16175"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/tags?post=16175"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}