{"id":15467,"date":"2021-01-05T01:23:47","date_gmt":"2021-01-04T22:23:47","guid":{"rendered":"https:\/\/www.klimikdergisi.org\/\/2021\/01\/05\/hematolojik-maligniteli-notropenik-hastalarda-daptomisin-tedavisinin-etkinligi\/"},"modified":"2021-01-05T01:23:47","modified_gmt":"2021-01-04T22:23:47","slug":"hematolojik-maligniteli-notropenik-hastalarda-daptomisin-tedavisinin-etkinligi","status":"publish","type":"post","link":"https:\/\/www.klimikdergisi.org\/tr\/2021\/01\/05\/hematolojik-maligniteli-notropenik-hastalarda-daptomisin-tedavisinin-etkinligi\/","title":{"rendered":"Hematolojik Maligniteli N\u00f6tropenik Hastalarda Daptomisin Tedavisinin Etkinli\u011fi"},"content":{"rendered":"<h1>\u00d6zet<\/h1>\n<p> <strong>Ama\u00e7<\/strong>: Bu \u00e7al\u0131\u015fmada hematolojik malignitesi olan n\u00f6tropenik hastalarda daptomisin (DAP)&#39;in etkinli\u011finin ara\u015ft\u0131r\u0131lmas\u0131 ama\u00e7lanm\u0131\u015ft\u0131r.<\/p>\n<p> <strong>Y\u00f6ntemler<\/strong>: Haziran 2011-Nisan 2013 tarihleri aras\u0131nda yeti\u015fkin hematoloji \u00fcnitesinde DAP alan n\u00f6tropenik hastalar incelendi. N\u00f6tropeni, ciddi (&lt;100 mm3), orta (101-499\/mm3) ve hafif (500-1000\/mm3) olarak s\u0131n\u0131fland\u0131r\u0131ld\u0131. DAP tedavisi sonras\u0131 klinik sonu\u00e7lar, k\u00fcr, k\u0131smi d\u00fczelme, tedavi ba\u015far\u0131s\u0131zl\u0131\u011f\u0131 ve tedavi yan\u0131t\u0131n\u0131n de\u011ferlendirilememesi olarak d\u00f6rt grupta kategorize edildi. Klinik ba\u015far\u0131 ise k\u00fcr ve k\u0131smi d\u00fczelme olan hastalar\u0131n toplam\u0131 olarak tan\u0131mland\u0131.<\/p>\n<p> <strong>Bulgular<\/strong>: DAP kullanan 43 n\u00f6tropenik hasta saptand\u0131. Hepsinde hematolojik malignite vard\u0131 ve 21 (%48.8) hastada ciddi n\u00f6tropeni mevcuttu. DAP \u00f6ncesinde hastalar\u0131n 40 (%93)\u2019\u0131n\u0131n ba\u015fka bir antibiyotik kulland\u0131\u011f\u0131 tespit edildi. Hastalardaki en s\u0131k tan\u0131, deri ve yumu\u015fak doku infeksiyonu (n=32)\u2019ydu. Hastalar\u0131n 12 (%27.9)\u2019sinde bir Gram-pozitif patojen izole edildi. En s\u0131k Gram-pozitif mikroorganizma Enterococcus faecium (n=7)\u2019du. DAP\u2019\u0131n ba\u015flang\u0131\u00e7 dozu t\u00fcm hastalarda 6 mg\/kg ve ortalama tedavi s\u00fcresi 15.5 g\u00fcn (min.=2, maks.=45 g\u00fcn)\u2019d\u00fc. DAP\u2019\u0131n genel klinik ba\u015far\u0131 h\u0131z\u0131 %82.5 (33\/40) olarak bulundu. Ciddi, orta ve hafif n\u00f6tropeni varl\u0131\u011f\u0131nda DAP\u2019\u0131n klinik ba\u015far\u0131 h\u0131zlar\u0131 s\u0131ras\u0131yla %84, %72 ve %90\u2019d\u0131. Birinci basamakta DAP kullan\u0131lan hastalarda ba\u015far\u0131 h\u0131z\u0131 %100 (12\/12) iken, ikinci basamakta tedavi olarak DAP\u2019a ge\u00e7ilenlerdeki ba\u015far\u0131 h\u0131z\u0131 %75 (21\/28)\u2019ti. Tedavi ba\u015far\u0131s\u0131 bakteriyemilerde %83, deri ve yumu\u015fak doku infeksiyonlar\u0131nda %81\u2019di. DAP ile ili\u015fkilendirilen bir yan etki saptanmad\u0131.<\/p>\n<p> <strong>Sonu\u00e7lar<\/strong>: Verilerimiz, n\u00f6tropenik hematolojik maligniteli hastalarda, Gram-pozitif infeksiyonlar\u0131n, birinci ve ikinci basamak tedavilerinde DAP&#39;\u0131n etkin oldu\u011funa i\u015faret etmektedir.\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u00d6zet Ama\u00e7: Bu \u00e7al\u0131\u015fmada hematolojik malignitesi olan n\u00f6tropenik hastalarda daptomisin (DAP)&#39;in etkinli\u011finin ara\u015ft\u0131r\u0131lmas\u0131 ama\u00e7lanm\u0131\u015ft\u0131r. Y\u00f6ntemler: Haziran 2011-Nisan 2013 tarihleri aras\u0131nda yeti\u015fkin hematoloji \u00fcnitesinde DAP alan n\u00f6tropenik hastalar incelendi. N\u00f6tropeni, ciddi (&lt;100 mm3), orta (101-499\/mm3) ve hafif (500-1000\/mm3) olarak s\u0131n\u0131fland\u0131r\u0131ld\u0131. DAP tedavisi sonras\u0131 klinik sonu\u00e7lar, k\u00fcr, k\u0131smi d\u00fczelme, tedavi ba\u015far\u0131s\u0131zl\u0131\u011f\u0131 ve tedavi yan\u0131t\u0131n\u0131n de\u011ferlendirilememesi olarak d\u00f6rt [&hellip;]<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5129],"tags":[3987,4466,4464,3581],"class_list":["post-15467","post","type-post","status-publish","format-standard","hentry","category-ozgun-arastirma","tag-daptomisin","tag-grampozitif-bakteriyel-infeksiyonlar","tag-hematolojik-neoplazmalar","tag-notropeni"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts\/15467","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/comments?post=15467"}],"version-history":[{"count":0,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts\/15467\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/media?parent=15467"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/categories?post=15467"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/tags?post=15467"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}