K\u0131r\u0131m-Kongo kanamal\u0131 ate\u015fi (KKKA), d\u00fcnyada en yayg\u0131n olarak g\u00f6r\u00fclen viral kanamal\u0131 ate\u015flerin ba\u015f\u0131nda gelir. KKKA virusu kene arac\u0131l\u0131\u011f\u0131yla veya infekte insan veya hayvanlar\u0131n kan ve v\u00fccut s\u0131v\u0131lar\u0131na temas sonucunda bula\u015f\u0131r. Tedavide s\u0131v\u0131 replasman\u0131 ve kan \u00fcr\u00fcnleri kullan\u0131m\u0131n\u0131n yan\u0131 s\u0131ra antiviral ila\u00e7 olan ribavirin kullan\u0131m\u0131 de\u011ferlendirilmelidir. Antiviral alternatifler aras\u0131nda ribavirin, in vitro \u00e7al\u0131\u015fmalarda KKKA virusuna kar\u015f\u0131 en etkili olan ila\u00e7t\u0131r. Ribavirin, g\u00f6zlemsel \u00e7al\u0131\u015fmalarda yararl\u0131 bulunmu\u015ftur. Plasebo kontroll\u00fc randomize kontroll\u00fc \u00e7al\u0131\u015fmalar Helsinki deklarasyonuna g\u00f6re etik d\u0131\u015f\u0131d\u0131r. KKKA\u2019da ribavirin \u00f6zellikle erken d\u00f6nemde verildi\u011fi zaman etkilidir. Erken d\u00f6nemden sonra steroid kullan\u0131m\u0131n\u0131n da yararl\u0131 olabilece\u011fi ileri s\u00fcr\u00fclm\u00fc\u015ft\u00fcr. Ribavirin ba\u015flan\u0131rken ciddiyet skorlamas\u0131 yap\u0131lmas\u0131 \u00f6nerilmektedir. Konvalesan imm\u00fcn globulin uygulamas\u0131n\u0131n yarar\u0131 g\u00f6sterilememi\u015ftir. Sa\u011fl\u0131k \u00e7al\u0131\u015fanlar\u0131nda KKKA ile y\u00fcksek riskli temas olmas\u0131 durumunda mutlaka ribavirinle profilaksi yap\u0131lmas\u0131 \u00f6nerilir. Bug\u00fcne kadar temas sonras\u0131 ribavirin ba\u015flananlarda \u00f6l\u00fcm g\u00f6r\u00fclmemi\u015ftir. Ribavirinin temas sonras\u0131 profilakside yararl\u0131 oldu\u011funu kabul etmek, ilac\u0131n hastal\u0131\u011f\u0131n erken d\u00f6neminde de etkili oldu\u011funu kabul etmek anlam\u0131na gelmektedir.\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"
\u00d6zet K\u0131r\u0131m-Kongo kanamal\u0131 ate\u015fi (KKKA), d\u00fcnyada en yayg\u0131n olarak g\u00f6r\u00fclen viral kanamal\u0131 ate\u015flerin ba\u015f\u0131nda gelir. KKKA virusu kene arac\u0131l\u0131\u011f\u0131yla veya infekte insan veya hayvanlar\u0131n kan ve v\u00fccut s\u0131v\u0131lar\u0131na temas sonucunda bula\u015f\u0131r. Tedavide s\u0131v\u0131 replasman\u0131 ve kan \u00fcr\u00fcnleri kullan\u0131m\u0131n\u0131n yan\u0131 s\u0131ra antiviral ila\u00e7 olan ribavirin kullan\u0131m\u0131 de\u011ferlendirilmelidir. Antiviral alternatifler aras\u0131nda ribavirin, in vitro \u00e7al\u0131\u015fmalarda KKKA virusuna […]<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5127],"tags":[4013,3874,4416],"class_list":["post-15311","post","type-post","status-publish","format-standard","hentry","category-derleme","tag-kirimkongo-kanamali-atesi-virusu","tag-ribavirin","tag-viral-kanamali-atesler"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts\/15311","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/comments?post=15311"}],"version-history":[{"count":0,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts\/15311\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/media?parent=15311"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/categories?post=15311"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/tags?post=15311"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}