Hepatit B virusu (HBV)\u2019nun replikasyon s\u0131ras\u0131nda olu\u015fturdu\u011fu y\u00fcksek viral kopya say\u0131s\u0131 ve ters transkriptaz enziminin hata d\u00fczeltme (\u201cproofreading\u201d) aktivitesinden yoksun olmas\u0131na ba\u011fl\u0131 olarak, HBV genotipleri, subgenotipleri, mutantlar ve rekombinantlar meydana gelmektedir. G\u00fcn\u00fcm\u00fcze kadar HBV\u2019nin A'dan J\u2019ye kadar 10 farkl\u0131 genotipi ve 40\u2019a yak\u0131n subgenotipi tan\u0131mlanm\u0131\u015ft\u0131r. Kuzeybat\u0131 Avrupa, Kuzey Amerika ve Afrika\u2019da genotip A; Asya \u00fclkelerinde genotip B ve C yayg\u0131n olarak g\u00f6r\u00fcl\u00fcrken; genotip C Do\u011fu ve G\u00fcneydo\u011fu Asya \u00fclkelerinde daha bask\u0131n olarak g\u00f6r\u00fclmektedir. Genotip D, t\u00fcm d\u00fcnya genelinde yayg\u0131n olmakla birlikte Akdeniz B\u00f6lgesi, Yak\u0131n Do\u011fu ve Ortado\u011fu \u00fclkeleriyle G\u00fcney Asya\u2019da daha s\u0131k g\u00f6r\u00fclmektedir. Bat\u0131 Afrika\u2019da genotip E; Orta ve G\u00fcney Amerika\u2019da\u00a0 genotip F daha bask\u0131nd\u0131r. Genotip G ise Fransa, Almanya ve Amerika\u2019dan bildirilmi\u015ftir. Genotip H, Orta Amerika\u2019da bulunmaktad\u0131r. Yeni tan\u0131mlanan genotip I ise genotip A, C ve G\u2019nin genotipik rekombinasyonu olarak ortaya \u00e7\u0131km\u0131\u015f olup Vietnam ve Laos\u2019tan izole edilmi\u015ftir. En yeni genotip olan genotip J, Japonya\u2019n\u0131n Ryukyu adalar\u0131nda tan\u0131mlanm\u0131\u015ft\u0131r ve bu genotipin gibon\/orangutan genotipleri ve insan genotip C\u2019siyle yak\u0131n ili\u015fkisi bulunmaktad\u0131r. Bu derlemede, HBV\u2019nin g\u00fcn\u00fcm\u00fcze kadar tan\u0131mlanm\u0131\u015f genotip ve subgenotipleri, co\u011frafi yay\u0131l\u0131m\u0131 ve klinik tablolarla ili\u015fkisi g\u00f6zden ge\u00e7irilmi\u015ftir.<\/p>\n","protected":false},"excerpt":{"rendered":"
\u00d6zet Hepatit B virusu (HBV)\u2019nun replikasyon s\u0131ras\u0131nda olu\u015fturdu\u011fu y\u00fcksek viral kopya say\u0131s\u0131 ve ters transkriptaz enziminin hata d\u00fczeltme (\u201cproofreading\u201d) aktivitesinden yoksun olmas\u0131na ba\u011fl\u0131 olarak, HBV genotipleri, subgenotipleri, mutantlar ve rekombinantlar meydana gelmektedir. G\u00fcn\u00fcm\u00fcze kadar HBV\u2019nin A'dan J\u2019ye kadar 10 farkl\u0131 genotipi ve 40\u2019a yak\u0131n subgenotipi tan\u0131mlanm\u0131\u015ft\u0131r. Kuzeybat\u0131 Avrupa, Kuzey Amerika ve Afrika\u2019da genotip A; Asya […]<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5127],"tags":[4553,3156,4555],"class_list":["post-15245","post","type-post","status-publish","format-standard","hentry","category-derleme","tag-genotip","tag-hepatit-b-virusu","tag-molekuler-epidemiyoloji"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts\/15245","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/comments?post=15245"}],"version-history":[{"count":0,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts\/15245\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/media?parent=15245"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/categories?post=15245"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/tags?post=15245"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}