HBsAg-pozitif, hematolojik maligniteli hastalarda y\u00fcksek doz kortikosteroid, rituksimab, antrasiklin grubu kemoterapi ajan\u0131 kullan\u0131lmas\u0131 ve k\u00f6k h\u00fccre nakli yap\u0131lmas\u0131 durumlar\u0131nda hepatit B reaktivasyonu geli\u015fme riski y\u00fcksektir. Literat\u00fcrde HBsAg-negatif, anti-HBc IgG- ve anti-HBs-pozitif olan, genellikle lenfoma tan\u0131l\u0131 hastalarda k\u00f6k h\u00fccre nakli yap\u0131ld\u0131\u011f\u0131nda ya da kemoterap\u00f6tik ajan olarak rituksimab kullan\u0131ld\u0131\u011f\u0131nda hepatit B virusu (HBV) reaktivasyonu bildirilmi\u015ftir. Olgu baz\u0131nda bortezomib kullanan ve\/veya k\u00f6k h\u00fccre nakli yap\u0131lan HBsAg-negatif, multipl myelom tan\u0131s\u0131 alm\u0131\u015f hastalarda da HBV reaktivasyonu geli\u015fti\u011fini g\u00f6steren yay\u0131nlar vard\u0131r. Bu yaz\u0131da multipl myelom tan\u0131l\u0131, HBV’ye kar\u015f\u0131, infeksiyonu ge\u00e7irerek ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131 geli\u015fmi\u015f; bortezomib kullan\u0131m\u0131 ve otolog k\u00f6k h\u00fccre nakli sonras\u0131 HBV reaktivasyonuna ba\u011fl\u0131 akut hepatit tablosu geli\u015fen ve lamivudinle ba\u015far\u0131yla tedavi edilen bir olgu sunulmu\u015ftur. Bu makalede HBV infeksiyonu ge\u00e7irerek ba\u011f\u0131\u015f\u0131kl\u0131k geli\u015ftirmi\u015f olan ve kemoterapi\/k\u00f6k h\u00fccre nakli yap\u0131lacak hastalarda reaktivasyon hepatiti geli\u015fme olas\u0131l\u0131\u011f\u0131na kar\u015f\u0131 hepatit B serolojik g\u00f6stergelerinin s\u0131k\u0131 takip edilmesi gerekti\u011fine dikkat \u00e7ekilmesi ama\u00e7lanm\u0131\u015ft\u0131r.<\/p>\n
Klimik Dergisi 2017; 30(3): 146-8.<\/p>\n
Cite this article as<\/strong>: Y\u0131lmaz-Karada\u011f F, Ergen P, \u00d6zt\u00fcrk E, Ayd\u0131n \u00d6. [Hepatitis B reactivation induced by bortezomib use and autologous bone marrow transplantation in a patient recovered from hepatitis B virus infection]. Klimik Derg. 2017; 30(3): 146-8. Turkish.<\/p>\n","protected":false},"excerpt":{"rendered":" \u00d6zet HBsAg-pozitif, hematolojik maligniteli hastalarda y\u00fcksek doz kortikosteroid, rituksimab, antrasiklin grubu kemoterapi ajan\u0131 kullan\u0131lmas\u0131 ve k\u00f6k h\u00fccre nakli yap\u0131lmas\u0131 durumlar\u0131nda hepatit B reaktivasyonu geli\u015fme riski y\u00fcksektir. Literat\u00fcrde HBsAg-negatif, anti-HBc IgG- ve anti-HBs-pozitif olan, genellikle lenfoma tan\u0131l\u0131 hastalarda k\u00f6k h\u00fccre nakli yap\u0131ld\u0131\u011f\u0131nda ya da kemoterap\u00f6tik ajan olarak rituksimab kullan\u0131ld\u0131\u011f\u0131nda hepatit B virusu (HBV) reaktivasyonu bildirilmi\u015ftir. Olgu […]<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5131],"tags":[4635,4603,4633,4223],"class_list":["post-14963","post","type-post","status-publish","format-standard","hentry","category-olgu-sunumu","tag-bortezomib","tag-hematopoetik-kok-hucre-nakli","tag-hepatit-b-reaktivasyonu","tag-multipl-myelom"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts\/14963","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/comments?post=14963"}],"version-history":[{"count":0,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts\/14963\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/media?parent=14963"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/categories?post=14963"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/tags?post=14963"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}