Pn\u00f6mokok hastal\u0131klar\u0131, bakteriyemik olan ya da olmayan pn\u00f6moni ba\u015fta olmak \u00fczere, \u00f6zellikle ya\u015fl\u0131larda ve imm\u00fcn sistemi zay\u0131flatan durumlar gibi birtak\u0131m sa\u011fl\u0131k sorunlar\u0131 olan eri\u015fkinlerde, t\u00fcm d\u00fcnyada \u00f6nemli bir morbidite ve mortalite nedeni olmaya devam etmektedir.\u00a0 \u00dclkemizde 13 valan konjuge pn\u00f6mokok a\u015f\u0131s\u0131 (KPA13) ve 23 valan polisakarid pn\u00f6mokok a\u015f\u0131s\u0131 (PPA23) olmak \u00fczere eri\u015fkinler i\u00e7in ruhsatland\u0131r\u0131lm\u0131\u015f iki a\u015f\u0131 vard\u0131r. PPA23 eri\u015fkinlerde y\u0131llard\u0131r kullan\u0131lmaktad\u0131r. 2008\u2019de 7 valan konjuge pn\u00f6mokok a\u015f\u0131s\u0131 (KPA7) \u00e7ocuklarda kullan\u0131lmak \u00fczere Geni\u015fletilmi\u015f Ba\u011f\u0131\u015f\u0131klama Program\u0131\u2019na al\u0131nm\u0131\u015ft\u0131r; daha sonra 2011\u2019de KPA7 yerini KPA13\u2019e b\u0131rakm\u0131\u015ft\u0131r. Yak\u0131nlarda Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131\u2019nca, Ba\u011f\u0131\u015f\u0131klama Dan\u0131\u015fma Kurulu kararlar\u0131 do\u011frultusunda, a\u015f\u0131yla \u00f6nlenebilir hastal\u0131klar a\u00e7\u0131s\u0131ndan risk gruplar\u0131 kabul edilmi\u015f ve bunlara uygulanmas\u0131 gereken, aralar\u0131nda eri\u015fkinlerde pn\u00f6mokok a\u015f\u0131lamas\u0131n\u0131n da bulundu\u011fu a\u015f\u0131 \u015femalar\u0131 y\u00fcr\u00fcrl\u00fc\u011fe konulmu\u015ftur. Bu \u015femalar, pn\u00f6mokok a\u015f\u0131lar\u0131 y\u00f6n\u00fcnden, KPA13\u2019\u00fcn hem y\u00fcksek risk alt\u0131ndaki eri\u015fkinlere hem de \u226565 ya\u015f\u0131ndaki t\u00fcm eri\u015fkinlere uygulanmas\u0131 gibi ABD\u2019deki g\u00fcncel Advisory Committee on Immunization Practices (ACIP) \u00f6nerileriyle b\u00fcy\u00fck \u00f6l\u00e7\u00fcde \u00f6rt\u00fc\u015fmektedir. Ayr\u0131ca, yak\u0131nlarda yay\u0131mlanan bir genelgeyle \u00fclkemizde de ba\u015flat\u0131laca\u011f\u0131 a\u00e7\u0131klanan invazif pn\u00f6mokok hastal\u0131klar\u0131 s\u00fcrveyans\u0131, A\u015f\u0131yla \u00d6nlenebilir \u0130nvazif Bakteriyel Hastal\u0131klar\u0131n S\u00fcrveyans\u0131 program\u0131n\u0131n kapsam\u0131na al\u0131nm\u0131\u015ft\u0131r. T\u00fcrk Klinik Mikrobiyoloji ve \u0130nfeksiyon Hastal\u0131klar\u0131 Derne\u011fi Eri\u015fkin Ba\u011f\u0131\u015f\u0131klamas\u0131 \u00c7al\u0131\u015fma Grubu\u2019nca haz\u0131rlanan bu uzla\u015f\u0131 raporunda ilgili literat\u00fcr ve uluslararas\u0131 \u00f6neriler g\u00f6zden ge\u00e7irilmi\u015f ve \u00fczerinde uzla\u015f\u0131lan \u00f6neriler sunulmu\u015ftur. Bu \u00f6nerilerden se\u00e7ilmi\u015f birka\u00e7\u0131 a\u015fa\u011f\u0131da s\u0131ralanm\u0131\u015ft\u0131r: [1] \u226565 ya\u015f\u0131ndaki herkese, y\u00fcksek risk alt\u0131ndaki her ya\u015ftan eri\u015fkinler (yani imm\u00fcn sistemi zay\u0131flatan durumu, fonksiyonel ya da anatomik asplenisi, beyin-omurilik s\u0131v\u0131s\u0131 ka\u00e7a\u011f\u0131 ve koklea implant\u0131 olan hastalar) gibi, \u00f6nce KPA13 ve sonra PPA23 uygulanmal\u0131d\u0131r. [2] Pn\u00f6mokok a\u015f\u0131lamas\u0131, pn\u00f6mokok hastal\u0131\u011f\u0131 y\u00f6n\u00fcnden risk alt\u0131nda olan (yani kronik kalp hastal\u0131\u011f\u0131, kronik akci\u011fer hastal\u0131\u011f\u0131, kronik karaci\u011fer hastal\u0131\u011f\u0131, alkolizm, diabetes mellitus\u2019u olan hastalar ve t\u00fct\u00fcn kullananlar gibi)\u00a0 <65 ya\u015f\u0131ndaki eri\u015fkinler i\u00e7in de \u00f6nerilir. Bu hastalara yaln\u0131z PPA23 uygulanmas\u0131 yeterlidir; ancak PPA23 \u00f6ncesinde KPA13 uygulanmas\u0131 da yararl\u0131 olabilir. [3] Her iki a\u015f\u0131n\u0131n uygulanmas\u0131n\u0131n gerekti\u011fi eri\u015fkinlere \u00f6nce KPA13 uygulanmal\u0131d\u0131r. [4] PPA23\u2019\u00fcn, imm\u00fcnokompetan eri\u015fkinlerin \u00e7o\u011funa KPA13\u2019ten \u22651 y\u0131l sonra uygulanmas\u0131na kar\u015f\u0131n; bu a\u015f\u0131 y\u00fcksek riskli hastalara \u22658 hafta sonra uygulanmal\u0131d\u0131r. [5] Daha \u00f6nce PPA23 uygulanm\u0131\u015f hastalara, bu uygulaman\u0131n \u00fczerinden \u22651 y\u0131l ge\u00e7meden KPA13 uygulanmamal\u0131d\u0131r. [6] \u0130mm\u00fcn sistemi zay\u0131flam\u0131\u015f ve asplenik hastalara PPA23\u2019\u00fcn ilk dozundan \u22655 y\u0131l sonra bir rapel dozu da uygulanmal\u0131d\u0131r. [7] KPA13 i\u00e7in hi\u00e7bir ya\u015f grubunda rapel dozu \u00f6nerilmemektedir. [8] Her iki a\u015f\u0131 da farkl\u0131 bir b\u00f6lgeye uygulanmak ko\u015fuluyla grip a\u015f\u0131s\u0131yla ayn\u0131 anda yap\u0131labilir. [9] \u00c7ocukluk \u00e7a\u011f\u0131 ba\u011f\u0131\u015f\u0131klamas\u0131nda kullan\u0131lan KPA13, toplumdaki a\u015f\u0131 su\u015flar\u0131n\u0131 ortadan kald\u0131rabildi\u011fi i\u00e7in, bu a\u015f\u0131 eri\u015fkinlerde beklenen yarar\u0131 s\u00fcrekli olarak sa\u011flamayabilir. Bu nedenle, serotip da\u011f\u0131l\u0131m\u0131 ve antibiyotik direnci h\u0131zlar\u0131 da dahil olmak \u00fczere lokal epidemiyolojinin anla\u015f\u0131lmas\u0131 i\u00e7in eri\u015fkin pn\u00f6mokok hastal\u0131klar\u0131n\u0131n s\u00fcrveyans\u0131 son derecede \u00f6nemlidir.<\/p>\n
Klimik Dergisi 2018; 31(\u00d6zel Say\u0131 1): 2-18<\/em>.<\/p>\n Cite this article as<\/strong>: \u015eenol E, Azap A, Erbay A, Alp-\u00c7avu\u015f S, Karaku\u015f R, Acar A. [Pneumococcal vaccine as one of the immunization coverage targets for adulthood vaccines: A consensus report of the Study Group for Adult Immunization of the Turkish Society of Clinical Microbiology and Infectious Diseases]. Klimik Derg. 2018; 31(Suppl. 1): 2-18. Turkish.<\/p>\n","protected":false},"excerpt":{"rendered":" \u00d6zet Pn\u00f6mokok hastal\u0131klar\u0131, bakteriyemik olan ya da olmayan pn\u00f6moni ba\u015fta olmak \u00fczere, \u00f6zellikle ya\u015fl\u0131larda ve imm\u00fcn sistemi zay\u0131flatan durumlar gibi birtak\u0131m sa\u011fl\u0131k sorunlar\u0131 olan eri\u015fkinlerde, t\u00fcm d\u00fcnyada \u00f6nemli bir morbidite ve mortalite nedeni olmaya devam etmektedir.\u00a0 \u00dclkemizde 13 valan konjuge pn\u00f6mokok a\u015f\u0131s\u0131 (KPA13) ve 23 valan polisakarid pn\u00f6mokok a\u015f\u0131s\u0131 (PPA23) olmak \u00fczere eri\u015fkinler i\u00e7in ruhsatland\u0131r\u0131lm\u0131\u015f […]<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5147],"tags":[4698,4700,4696],"class_list":["post-14807","post","type-post","status-publish","format-standard","hentry","category-uzlasi-raporu","tag-13-valan-konjuge-pnomokok-asisi","tag-23-valan-polisakarid-pnomokok-asisi","tag-eriskinde-pnomokok-asilamasi"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts\/14807","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/comments?post=14807"}],"version-history":[{"count":0,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts\/14807\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/media?parent=14807"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/categories?post=14807"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/tags?post=14807"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}