Ama\u00e7<\/strong>: Bu \u00e7al\u0131\u015fmada normal ve kistik fibrozlu bron\u015f epitelinde tigesiklin ve vankomisinin ula\u015fabilece\u011fi etkin h\u00fccre i\u00e7i konsantrasyonlar\u0131n, doz ve zaman parametrelerine ba\u011fl\u0131 olarak ara\u015ft\u0131r\u0131lmas\u0131 ama\u00e7lanm\u0131\u015ft\u0131r.<\/p>\n \u00d6zet Ama\u00e7: Bu \u00e7al\u0131\u015fmada normal ve kistik fibrozlu bron\u015f epitelinde tigesiklin ve vankomisinin ula\u015fabilece\u011fi etkin h\u00fccre i\u00e7i konsantrasyonlar\u0131n, doz ve zaman parametrelerine ba\u011fl\u0131 olarak ara\u015ft\u0131r\u0131lmas\u0131 ama\u00e7lanm\u0131\u015ft\u0131r. Y\u00f6ntemler: Tigesiklin ve vankomisin aras\u0131ndaki doz ve zamana ba\u011fl\u0131 h\u00fccre i\u00e7i konsantrasyonlar\u0131 y\u00f6n\u00fcnden farkl\u0131l\u0131klar, h\u00fccre k\u00fclt\u00fcr\u00fc ve y\u00fcksek performansl\u0131 s\u0131v\u0131 kromatografisiyle belirlenmi\u015ftir. Bulgular: Tigesiklinin kistik fibrozlu bron\u015f epiteline giri\u015fiyle […]<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5129],"tags":[4742,3906,2985],"class_list":["post-14735","post","type-post","status-publish","format-standard","hentry","category-ozgun-arastirma","tag-kistik-fibroz","tag-tigesiklin","tag-vankomisin"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts\/14735","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/comments?post=14735"}],"version-history":[{"count":0,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts\/14735\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/media?parent=14735"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/categories?post=14735"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/tags?post=14735"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
<\/br> Y\u00f6ntemler<\/strong>: Tigesiklin ve vankomisin aras\u0131ndaki doz ve zamana ba\u011fl\u0131 h\u00fccre i\u00e7i konsantrasyonlar\u0131 y\u00f6n\u00fcnden farkl\u0131l\u0131klar, h\u00fccre k\u00fclt\u00fcr\u00fc ve y\u00fcksek performansl\u0131 s\u0131v\u0131 kromatografisiyle belirlenmi\u015ftir.<\/p>\n
<\/br> Bulgular<\/strong>: Tigesiklinin kistik fibrozlu bron\u015f epiteline giri\u015fiyle normal h\u00fccreye giri\u015fi aras\u0131ndaki fark\u0131n, anlaml\u0131 olarak y\u00fcksek oldu\u011fu bulunmu\u015ftur. H\u00fccre i\u00e7ine giren miktar, uygulanan dozlarla kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, h\u00fccre i\u00e7ine optimal giri\u015fin oldu\u011fu doz 30 \u03bcg\/ml, zaman ise 8 saat olarak tespit edilmi\u015ftir. Vankomisinin h\u00fccre i\u00e7ine minimal miktarda girebilmesi i\u00e7in, k\u0131lavuzlarda belirtilen minimum inhibit\u00f6r konsantrasyonun \u00e7ok \u00fcst\u00fcndeki dozlarda vermek gerekti\u011fi tespit edilmi\u015ftir.<\/p>\n
<\/br> Sonu\u00e7lar<\/strong>: Tigesiklinin kistik fibrozlu bron\u015f epiteline giri\u015fi normal bron\u015f epiteline oranla daha y\u00fcksek bulunmu\u015ftur. Vankomisinin kistik fibrozlu ve normal bron\u015f epiteline giri\u015finin ise yok denecek kadar az oldu\u011fu tespit edilmi\u015ftir. Bu nedenle, tigesiklinin kistik fibrozlu hastalar\u0131n akci\u011fer infeksiyonlar\u0131nda y\u00fcksek bir terap\u00f6tik potansiyeli oldu\u011fu d\u00fc\u015f\u00fcn\u00fclm\u00fc\u015ft\u00fcr.<\/p>\n
<\/br> Cite this article as<\/strong>: G\u00fcnay N, Akar F, G\u00f6kbulut C, Sakarya S. [Determination of the differences in penetration of tigecycline and vancomycin into bronchial epithelium of normal and cystic fibrosis lung]. Klimik Derg. 2018; 31(2): 139-43. Turkish.<\/p>\n","protected":false},"excerpt":{"rendered":"