Ama\u00e7<\/strong>: \u00c7al\u0131\u015fmam\u0131zda \u0130stanbul \u015ei\u015fli Hamidiye Etfal E\u011fitim ve Ara\u015ft\u0131rma Hastanesi \u0130nfeksiyon Hastal\u0131klar\u0131 ve Klinik Mikrobiyoloji Klini\u011fi\u2019ne ba\u015fvuran ve HIV infeksiyonu saptanan hastalar\u0131n, demografik \u00f6zelliklerinin retrospektif olarak incelenmesi ve ba\u015flanan farkl\u0131 antiretroviral tedavi (ART) rejimlerine virolojik ve imm\u00fcnolojik yan\u0131t\u0131n kar\u015f\u0131la\u015ft\u0131r\u0131lmas\u0131 ama\u00e7lanm\u0131\u015ft\u0131r.<\/p>\n Y\u00f6ntemler<\/strong>: 2013-2015 tarihleri aras\u0131nda ba\u015fvuran 196 HIV\/AIDS hastas\u0131 \u00e7al\u0131\u015fma kapsam\u0131na al\u0131nd\u0131. Bu hastalar\u0131n cinsiyet ve ya\u015f bilgileri, ART ba\u015flang\u0131c\u0131ndaki, 4., 24. ve 48. haftas\u0131ndaki HIV RNA de\u011ferleri ve ART ba\u015flang\u0131c\u0131ndaki, 24. ve 48. haftas\u0131ndaki CD4+ T lenfositi say\u0131lar\u0131 de\u011ferlendirildi. Hastalar, ba\u015flanan ART rejimlerine g\u00f6re \u00fc\u00e7 gruba ayr\u0131larak, integraz inhibit\u00f6r\u00fc (INI), proteaz inhibit\u00f6r\u00fc (PI) ve nonn\u00fckleozid revers transkriptaz inhibit\u00f6r\u00fc (NNRTI) temelli rejimler, elde edilen virolojik ve imm\u00fcnolojik yan\u0131tlar a\u00e7\u0131s\u0131ndan kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131.<\/p>\n Bulgular<\/strong>: Hastalar\u0131n %93.4’\u00fc erkek olup, ya\u015f ortalamas\u0131 35.89\u00b110.83 y\u0131l olarak saptand\u0131. Hastalar\u0131n INI, NNRTI ve PI temelli ART rejimlerine g\u00f6re da\u011f\u0131l\u0131mlar\u0131, s\u0131ras\u0131yla %49.5, %8.2 ve %42.3 idi. Tedavi rejimleri aras\u0131nda 4. haftada virolojik yan\u0131t a\u00e7\u0131s\u0131ndan bir fark saptanmad\u0131. On ikinci ve 24. haftada INI temelli ART rejimlerine virolojik yan\u0131t daha ba\u015far\u0131l\u0131 bulundu. K\u0131rk sekizinci haftadaki virolojik yan\u0131t a\u00e7\u0131s\u0131ndan ART rejimleri aras\u0131nda bir fark saptanmad\u0131. \u0130mm\u00fcnolojik yan\u0131t a\u00e7\u0131s\u0131ndan 24. haftada ART rejimleri aras\u0131nda bir fark saptanmazken, 48. haftada INI ve PI temelli ART rejimlerine yan\u0131t\u0131n daha iyi oldu\u011fu g\u00f6zlendi.<\/p>\n Sonu\u00e7lar<\/strong>: \u00c7al\u0131\u015fmaya kat\u0131lan olgular\u0131m\u0131zda INI ve PI temelli ART rejimlerine virolojik ve imm\u00fcnolojik yan\u0131t, NNRTI rejimlere g\u00f6re daha iyi bulunmu\u015ftur. Bulgular\u0131m\u0131za g\u00f6re, naif hastalarda k\u0131lavuzlarda da belirtildi\u011fi gibi, ilkin INI rejimi, sonra PI rejimi ye\u011flenmelidir.\u00a0Klimik Dergisi 2019; 32(1): 13-8.<\/p>\n Cite this article as<\/strong>: Akkaya-I\u015f\u0131k S, G\u00fcnd\u00fcz A, \u00d6nc\u00fcl A, et al. [Comparison of antiretroviral therapy regimens with regard to virological and immunological response in treatment-naive HIV\/AIDS patients]. Klimik Derg. 2019; 32(1): 13-8. Turkish.<\/p>\n","protected":false},"excerpt":{"rendered":" \u00d6zet Ama\u00e7: \u00c7al\u0131\u015fmam\u0131zda \u0130stanbul \u015ei\u015fli Hamidiye Etfal E\u011fitim ve Ara\u015ft\u0131rma Hastanesi \u0130nfeksiyon Hastal\u0131klar\u0131 ve Klinik Mikrobiyoloji Klini\u011fi\u2019ne ba\u015fvuran ve HIV infeksiyonu saptanan hastalar\u0131n, demografik \u00f6zelliklerinin retrospektif olarak incelenmesi ve ba\u015flanan farkl\u0131 antiretroviral tedavi (ART) rejimlerine virolojik ve imm\u00fcnolojik yan\u0131t\u0131n kar\u015f\u0131la\u015ft\u0131r\u0131lmas\u0131 ama\u00e7lanm\u0131\u015ft\u0131r. Y\u00f6ntemler: 2013-2015 tarihleri aras\u0131nda ba\u015fvuran 196 HIV\/AIDS hastas\u0131 \u00e7al\u0131\u015fma kapsam\u0131na al\u0131nd\u0131. Bu hastalar\u0131n cinsiyet […]<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5129],"tags":[4758,3228,4760,3837],"class_list":["post-14417","post","type-post","status-publish","format-standard","hentry","category-ozgun-arastirma","tag-antiretroviral-ajanlar","tag-hiv","tag-immunolojik-yanit","tag-virolojik-yanit"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts\/14417","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/comments?post=14417"}],"version-history":[{"count":0,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts\/14417\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/media?parent=14417"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/categories?post=14417"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/tags?post=14417"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}