{"id":14045,"date":"2021-01-05T01:21:52","date_gmt":"2021-01-04T22:21:52","guid":{"rendered":"https:\/\/www.klimikdergisi.org\/\/2021\/01\/05\/akdeniz-universitesi-hastanesinde-izlenen-yetiskin-hastalarda-kandidemi-epidemiyolojisi-candida-turlerinin-antifungal-duyarliliklari-ve-mortalite-uzerine-etkileri\/"},"modified":"2021-01-05T01:21:52","modified_gmt":"2021-01-04T22:21:52","slug":"akdeniz-universitesi-hastanesinde-izlenen-yetiskin-hastalarda-kandidemi-epidemiyolojisi-candida-turlerinin-antifungal-duyarliliklari-ve-mortalite-uzerine-etkileri","status":"publish","type":"post","link":"https:\/\/www.klimikdergisi.org\/tr\/2021\/01\/05\/akdeniz-universitesi-hastanesinde-izlenen-yetiskin-hastalarda-kandidemi-epidemiyolojisi-candida-turlerinin-antifungal-duyarliliklari-ve-mortalite-uzerine-etkileri\/","title":{"rendered":"Akdeniz \u00dcniversitesi Hastanesi’nde \u0130zlenen Yeti\u015fkin Hastalarda Kandidemi Epidemiyolojisi, Candida T\u00fcrlerinin Antifungal Duyarl\u0131l\u0131klar\u0131 ve Mortalite \u00dczerine Etkileri"},"content":{"rendered":"

Ama\u00e7<\/strong>: Bu ara\u015ft\u0131rmada, yeti\u015fkin hastalarda hastane kaynakl\u0131 kandidemi epidemiyolojisi, s\u0131kl\u0131\u011f\u0131, bilinen risk fakt\u00f6rlerinin prevalans\u0131, t\u00fcrlerin da\u011f\u0131l\u0131m\u0131, antifungal duyarl\u0131l\u0131klar\u0131 ve mortalite \u00fczerine etkilerinin ortaya konulmas\u0131 ama\u00e7lanm\u0131\u015ft\u0131r.<\/p>\n

Y\u00f6ntemler<\/strong>: 1 A\u011fustos 2014-31 May\u0131s 2016 tarihleri aras\u0131nda Akdeniz \u00dcniversitesi Hastanesi yatakl\u0131 servisleri ve yo\u011fun bak\u0131m \u00fcnitelerinde yatan ve yat\u0131\u015ftan 48 saat sonra en az bir kan k\u00fclt\u00fcr\u00fcnde Candida spp. \u00fcreyerek hastane kaynakl\u0131 kandidemi tan\u0131s\u0131 alan 18 ya\u015f \u00fcst\u00fc 102 hasta prospektif olarak de\u011ferlendirilmi\u015ftir. \u00dcreyen Candida su\u015flar\u0131 t\u00fcr d\u00fczeyinde tiplendirilmi\u015ftir. Antifungal duyarl\u0131l\u0131klar\u0131 Sensititre\u2122 YeastOne\u2122 (TREK Diagnostics, Thermo Fisher Scientific, East Grinstead, Birle\u015fik Krall\u0131k) paneliyle belirlenmi\u015ftir. Sonu\u00e7lar Clinical and Laboratory Standards Institute (CLSI) M27-S4 ve M60 dok\u00fcmanlar\u0131na g\u00f6re de\u011ferlendirilmi\u015ftir.<\/p>\n

Bulgular<\/strong>: \u00c7al\u0131\u015fmada kandidemi insidans h\u0131z\u0131 1000 ba\u015fvuruda 1.22 vaka olarak bulunmu\u015ftur. 102 hastan\u0131n %36.3\u2019\u00fcnde etken Candida albicans iken, % 63.7\u2019sinde albicans d\u0131\u015f\u0131 Candida t\u00fcrleridir. En s\u0131k g\u00f6r\u00fclen albicans d\u0131\u015f\u0131 Candida t\u00fcrleri, C. parapsilosis (%22.5), C. tropicalis (%16.7) ve C. glabrata (%12.7)\u2019d\u0131r. En s\u0131k g\u00f6r\u00fclen risk fakt\u00f6rleri geni\u015f spektrumlu antibiyotik kullan\u0131m\u0131 (%98) ve idrar sondas\u0131 varl\u0131\u011f\u0131 (%96.1) olarak saptanm\u0131\u015ft\u0131r. Ekinokandinler t\u00fcm Candida t\u00fcrlerine kar\u015f\u0131 iyi aktivite g\u00f6stermi\u015ftir. C. parapsilosis izolatlar\u0131n\u0131n %8.7'sinde flukonazole ve %4.4'\u00fcnde vorikonazole diren\u00e7 saptanm\u0131\u015ft\u0131r. C. tropicalis izolatlar\u0131n\u0131n %5.9'unda flukonazole ve %5.9'unda vorikonazole diren\u00e7 saptanm\u0131\u015ft\u0131r. Flukonazole diren\u00e7li iki C. parapsilosis ve bir C. tropicalis su\u015funda vorikonazole \u00e7apraz diren\u00e7 saptanm\u0131\u015ft\u0131r. T\u00fcm su\u015flar posakonazol ve amfoterisin B\u2019nin epidemiyolojik e\u015fik de\u011ferlerine g\u00f6re vah\u015fi su\u015f olarak de\u011ferlendirilmi\u015ftir. Kandidemiyle ili\u015fkili kaba mortalite oran\u0131 %79.3\u2019t\u00fc. Mekanik ventilasyon, santral ven\u00f6z kateter kullan\u0131m\u0131 ve total parenteral n\u00fctrisyon deste\u011fi mortaliteyi art\u0131rm\u0131\u015ft\u0131r.<\/p>\n

Sonu\u00e7lar<\/strong>: Merkezimizde antifungal ajanlara duyarl\u0131l\u0131\u011f\u0131 azalan ve intrensek diren\u00e7li olan Candida t\u00fcrleri hen\u00fcz sorun olu\u015fturmamakla birlikte, kandidemi etkeni Candida su\u015flar\u0131 i\u00e7in t\u00fcr tan\u0131mlamas\u0131 ve antifungal duyarl\u0131l\u0131k testlerinin yap\u0131lmas\u0131 gerekmektedir.<\/p>\n

Klimik Dergisi 2019; 32(3): 250-8.<\/p>\n

Cite this article as<\/strong>: Kolak \u00c7\u00c7, Erman-Dalo\u011flu A, \u00d6zhak B, \u00d6\u011f\u00fcn\u00e7 D, G\u00fcnseren F. [Epidemiology of candidemia, antifungal susceptibilities of Candida species and their impact on mortality in adult patients admitted to Akdeniz University Hospital]. Klimik Derg. 2019; 32(3): 250-8. Turkish.<\/p>\n","protected":false},"excerpt":{"rendered":"

Ama\u00e7: Bu ara\u015ft\u0131rmada, yeti\u015fkin hastalarda hastane kaynakl\u0131 kandidemi epidemiyolojisi, s\u0131kl\u0131\u011f\u0131, bilinen risk fakt\u00f6rlerinin prevalans\u0131, t\u00fcrlerin da\u011f\u0131l\u0131m\u0131, antifungal duyarl\u0131l\u0131klar\u0131 ve mortalite \u00fczerine etkilerinin ortaya konulmas\u0131 ama\u00e7lanm\u0131\u015ft\u0131r. Y\u00f6ntemler: 1 A\u011fustos 2014-31 May\u0131s 2016 tarihleri aras\u0131nda Akdeniz \u00dcniversitesi Hastanesi yatakl\u0131 servisleri ve yo\u011fun bak\u0131m \u00fcnitelerinde yatan ve yat\u0131\u015ftan 48 saat sonra en az bir kan k\u00fclt\u00fcr\u00fcnde Candida spp. […]<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5129],"tags":[4876,3235,4483],"class_list":["post-14045","post","type-post","status-publish","format-standard","hentry","category-ozgun-arastirma","tag-antifungal-agents","tag-candida","tag-candidemia"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts\/14045","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/comments?post=14045"}],"version-history":[{"count":0,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts\/14045\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/media?parent=14045"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/categories?post=14045"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/tags?post=14045"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}