{"id":14027,"date":"2021-01-05T01:21:51","date_gmt":"2021-01-04T22:21:51","guid":{"rendered":"https:\/\/www.klimikdergisi.org\/\/2021\/01\/05\/idrar-kulturlerinden-izole-edilen-enterik-bakterilerde-genislemis-spektrumlu-laktamaz-olusturma-sikligi-ve-antibiyotik-duyarliliklari\/"},"modified":"2021-01-05T01:21:51","modified_gmt":"2021-01-04T22:21:51","slug":"idrar-kulturlerinden-izole-edilen-enterik-bakterilerde-genislemis-spektrumlu-laktamaz-olusturma-sikligi-ve-antibiyotik-duyarliliklari","status":"publish","type":"post","link":"https:\/\/www.klimikdergisi.org\/tr\/2021\/01\/05\/idrar-kulturlerinden-izole-edilen-enterik-bakterilerde-genislemis-spektrumlu-laktamaz-olusturma-sikligi-ve-antibiyotik-duyarliliklari\/","title":{"rendered":"\u0130drar K\u00fclt\u00fcrlerinden \u0130zole Edilen Enterik Bakterilerde Geni\u015flemi\u015f Spektrumlu β-Laktamaz Olu\u015fturma S\u0131kl\u0131\u011f\u0131 ve Antibiyotik Duyarl\u0131l\u0131klar\u0131"},"content":{"rendered":"

Ama\u00e7<\/strong>: Bu \u00e7al\u0131\u015fmada, hastanemizdeki ayaktan ve yatan hastalar\u0131n anlaml\u0131 bakteri\u00fcri saptanan idrar k\u00fclt\u00fcrlerinde \u00fcreyen patojen mikroorganizmalar\u0131n da\u011f\u0131l\u0131m\u0131n\u0131n, Enterobacteriaceae \u00fcyeleri aras\u0131nda geni\u015flemi\u015f spektrumlu \u03b2-laktamaz (GSBL) olu\u015fturma s\u0131kl\u0131\u011f\u0131n\u0131n ve antibiyotiklere duyarl\u0131l\u0131\u011f\u0131n ara\u015ft\u0131r\u0131lmas\u0131 ama\u00e7lanm\u0131\u015ft\u0131r.<\/p>\n

Y\u00f6ntemler<\/strong>: Ocak 2016-Aral\u0131k 2017 tarihleri aras\u0131nda hastanemiz mikrobiyoloji laboratuvar\u0131na \u00e7e\u015fitli birimlerden g\u00f6nderilen idrarlardan py\u00fcri saptanan ve k\u00fclt\u00fcrlerinde anlaml\u0131 bakteri\u00fcri olanlar \u00e7al\u0131\u015fmaya dahil edilmi\u015ftir. \u00dcreyen bakterilerin tan\u0131mlanmas\u0131, duyarl\u0131l\u0131k testleri ve GSBL yap\u0131m\u0131n\u0131n ara\u015ft\u0131r\u0131lmas\u0131 VITEK\u00ae 2 otomatize sistemiyle yap\u0131lm\u0131\u015ft\u0131r.<\/p>\n

Bulgular<\/strong>: \u00c7al\u0131\u015fmam\u0131zda toplam 4352 idrar \u00f6rne\u011finde anlaml\u0131 bakteri\u00fcri saptand\u0131. En s\u0131k izole edilen mikroorganizmalar Escherichia coli, Klebsiella spp. ve Enterococcus spp. idi. Enterobacteriaceae su\u015flar\u0131n\u0131n %17.9\u2019unda GSBL pozitifli\u011fi saptand\u0131. GSBL pozitifli\u011fi erkeklerde, yatan hastalarda ve 65 ya\u015f \u00fczerinde daha s\u0131kt\u0131 (p<0.001). GSBL varl\u0131\u011f\u0131nda fosfomisin ve nitrofurantoin hari\u00e7 di\u011fer antibiyotiklerin duyarl\u0131l\u0131\u011f\u0131 istatistiksel olarak anlaml\u0131 d\u00fczeyde d\u00fc\u015f\u00fck saptand\u0131. Ayaktan ve yatan hastalarda E. coli ve Klebsiella spp. i\u00e7in duyarl\u0131l\u0131k durumlar\u0131 incelendi\u011finde yatan hastalarda \u00e7o\u011fu antibiyoti\u011fin duyarl\u0131l\u0131\u011f\u0131 daha d\u00fc\u015f\u00fck d\u00fczeydeydi. Hem E. coli hem de Klebsiella spp. i\u00e7in ayaktan hastalarda kullan\u0131labilecek se\u00e7enekler aras\u0131nda su\u015flar\u0131n duyarl\u0131l\u0131\u011f\u0131n\u0131n en y\u00fcksek oldu\u011fu antibiyotikler nitrofurantoin ve fosfomisin, en d\u00fc\u015f\u00fck oldu\u011fu antibiyotikler ise amoksisilin-klavulanat, trimetoprim-s\u00fclfametoksazol ve siprofloksasindi. En etkili parenteral ajanlar, piperasilin-tazobaktam, karbapenemler ve aminoglikozidlerdi.<\/p>\n

Sonu\u00e7lar<\/strong>: Ayaktan ve yatan hastalarda idrar yolu infeksiyonlar\u0131na yol a\u00e7an mikroorganizmalar\u0131n da\u011f\u0131l\u0131m\u0131n\u0131n ve antibiyotik diren\u00e7 paternlerinin farkl\u0131l\u0131\u011f\u0131 nedeniyle, mikrobiyolojik verilerin belirli aral\u0131klarla b\u00f6lgesel olarak takip edilmesi, \u00f6zellikle ampirik tedavi plan\u0131 a\u00e7\u0131s\u0131ndan klinisyenlere yol g\u00f6sterecektir.\u00a0<\/p>\n

Klimik Dergisi 2019; 32(3): 233-9.<\/p>\n

Cite this article as<\/strong>: Karamanl\u0131o\u011flu D, Aysert-Y\u0131ld\u0131z P, Kaya M, Sar\u0131 N. [Extended-spectrum \u03b2-lactamase production rates and antibiotic susceptibilities among Enterobacteriaceae isolated from urine]. Klimik Derg. 2019; 32(3): 233-9. Turkish.<\/p>\n","protected":false},"excerpt":{"rendered":"

Ama\u00e7: Bu \u00e7al\u0131\u015fmada, hastanemizdeki ayaktan ve yatan hastalar\u0131n anlaml\u0131 bakteri\u00fcri saptanan idrar k\u00fclt\u00fcrlerinde \u00fcreyen patojen mikroorganizmalar\u0131n da\u011f\u0131l\u0131m\u0131n\u0131n, Enterobacteriaceae \u00fcyeleri aras\u0131nda geni\u015flemi\u015f spektrumlu \u03b2-laktamaz (GSBL) olu\u015fturma s\u0131kl\u0131\u011f\u0131n\u0131n ve antibiyotiklere duyarl\u0131l\u0131\u011f\u0131n ara\u015ft\u0131r\u0131lmas\u0131 ama\u00e7lanm\u0131\u015ft\u0131r. Y\u00f6ntemler: Ocak 2016-Aral\u0131k 2017 tarihleri aras\u0131nda hastanemiz mikrobiyoloji laboratuvar\u0131na \u00e7e\u015fitli birimlerden g\u00f6nderilen idrarlardan py\u00fcri saptanan ve k\u00fclt\u00fcrlerinde anlaml\u0131 bakteri\u00fcri olanlar \u00e7al\u0131\u015fmaya dahil edilmi\u015ftir. \u00dcreyen […]<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5129],"tags":[3446,4355,4975],"class_list":["post-14027","post","type-post","status-publish","format-standard","hentry","category-ozgun-arastirma","tag-enterobacteriaceae","tag-genislemis-spektrumlu-laktamazlar","tag-idrar-kulturleri"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts\/14027","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/comments?post=14027"}],"version-history":[{"count":0,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts\/14027\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/media?parent=14027"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/categories?post=14027"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/tags?post=14027"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}