{"id":13967,"date":"2021-01-05T01:21:46","date_gmt":"2021-01-04T22:21:46","guid":{"rendered":"https:\/\/www.klimikdergisi.org\/\/2021\/01\/05\/moksifloksasin-kullaniminda-hiponatremi-sikligi\/"},"modified":"2021-01-05T01:21:46","modified_gmt":"2021-01-04T22:21:46","slug":"moksifloksasin-kullaniminda-hiponatremi-sikligi","status":"publish","type":"post","link":"https:\/\/www.klimikdergisi.org\/tr\/2021\/01\/05\/moksifloksasin-kullaniminda-hiponatremi-sikligi\/","title":{"rendered":"Moksifloksasin Kullan\u0131m\u0131nda Hiponatremi S\u0131kl\u0131\u011f\u0131"},"content":{"rendered":"

Ama\u00e7<\/strong>: Hiponatremi, serum sodyum d\u00fczeyinin 135 mmol\/lt\u2019nin alt\u0131nda olmas\u0131d\u0131r. Bu \u00e7al\u0131\u015fman\u0131n amac\u0131, moksifloksasin tedavisi alan hastalarda hiponatremi geli\u015fme s\u0131kl\u0131\u011f\u0131n\u0131 ara\u015ft\u0131rmak ve moksifloksasinin hiponatremi d\u00fczeylerine inmemi\u015f olsa bile serum sodyum d\u00fczeylerinde bir de\u011fi\u015fikli\u011fe sebep olup olmad\u0131\u011f\u0131n\u0131 incelemektir.<\/p>\n

Y\u00f6ntemler<\/strong>: Ara\u015ft\u0131rma grubu moksifloksasin tedavisi alm\u0131\u015f 36 hastan\u0131n dosyalar\u0131n\u0131n ve Hastane Bilgi Y\u00f6netim Sistemi verilerinin ge\u00e7mi\u015fe y\u00f6nelik olarak taranmas\u0131yla olu\u015fturuldu. 5-7 g\u00fcn moksifloksasin tedavisi alanlarda, tedavi \u00f6ncesi 3 g\u00fcne, tedavi boyunca ilk 2 g\u00fcne, 3-4. g\u00fcne, 5-7. g\u00fcne ve tedavi sonras\u0131 3 g\u00fcne ait bir sodyum de\u011feri kaydedildi. Daha uzun (8-14 g\u00fcn) tedavi alanlarda ise ek olarak 8-14. g\u00fcne ait bir sodyum de\u011feri daha kaydedildi. Her bir hasta g\u00fcn gruplar\u0131 aras\u0131nda hiponatremi a\u00e7\u0131s\u0131ndan incelendi. Ayr\u0131ca hastalar tedavi s\u00fcresi (5-7 g\u00fcn tedavi alanlar ve 8-14 g\u00fcn tedavi alanlar \u015feklinde 2 grup olarak), cinsiyet, tedavi \u015fekline (oral ve intraven\u00f6z) g\u00f6re gruplara ayr\u0131ld\u0131. Gruplar aras\u0131ndaki fark, Statistical Package for the Social Sciences (SPSS) for Windows. Version 16.0 (SPSS Inc., Chicago, IL, ABD) istatistik program\u0131nda ba\u011f\u0131ms\u0131z t-testi kullan\u0131larak incelendi.<\/p>\n

Bulgular<\/strong>: \u00c7al\u0131\u015fma grubunu olu\u015fturan 36 hastadan (ya\u015f ortalamas\u0131 60.78\u00b115.93), 22\u2019si erkek (ya\u015f ortalamas\u0131 58.64\u00b115.51), 14\u2019\u00fc kad\u0131nd\u0131 (ya\u015f ortalamas\u0131: 64.14\u00b116.58). Bunlar\u0131n 20\u2019si 5-7 g\u00fcnl\u00fck, 16\u2019s\u0131 ise 8-14 g\u00fcnl\u00fck moksifloksasin tedavisi uygulanan hastalard\u0131. 13\u2019\u00fc oral, 23\u2019\u00fc intraven\u00f6z moksifloksasin tedavisi ald\u0131. D\u00f6rt hasta moksifloksasin tedavisine ba\u015flanmadan \u00f6nce de hiponatremikti. Kalan 32 hastan\u0131n 3\u2019\u00fcnde tedavinin ilk 2 g\u00fcn\u00fc, 9\u2019unda 3-4. g\u00fcn\u00fc, 3\u2019\u00fcnde 5-7. g\u00fcn\u00fc ve 2\u2019sinde 8-14. g\u00fcn\u00fc ba\u015flamak \u00fczere toplam 17 (%53.1) hastada hiponatremi geli\u015fti. G\u00fcn gruplar\u0131 aras\u0131nda istatistiksel olarak anlaml\u0131 farklar vard\u0131. Tedavi s\u00fcresi ve tedavi \u015fekline g\u00f6re sodyum d\u00fczeyleri bak\u0131m\u0131ndan saptanan farklar istatistiksel olarak anlaml\u0131 bulunmad\u0131. Kad\u0131nlarda daha y\u00fcksek sodyum ortalamas\u0131 olmas\u0131na ra\u011fmen aradaki fark istatistiksel olarak anlaml\u0131 de\u011fildi (p=0.125).<\/p>\n

Sonu\u00e7lar<\/strong>: Moksifloksasinle hiponatremi aras\u0131nda tedavi s\u00fcresine g\u00f6re de\u011fi\u015fkenlik g\u00f6steren istatistiksel olarak anlaml\u0131 bir ili\u015fki saptad\u0131k. Bu verilerin daha fazla olguyu i\u00e7eren klinik \u00e7al\u0131\u015fmalarla do\u011frulanmas\u0131na gereksinim vard\u0131r.<\/p>\n

Klimik Dergisi 2020; 33(1): 82-6.<\/p>\n

Cite this article as<\/strong>: \u015eeker R, Ademo\u011flu D. [Frequency of hyponatremia during moxifloxacin use]. Klimik Derg. 2020; 33(1): 82-6. Turkish.<\/p>\n","protected":false},"excerpt":{"rendered":"

Ama\u00e7: Hiponatremi, serum sodyum d\u00fczeyinin 135 mmol\/lt\u2019nin alt\u0131nda olmas\u0131d\u0131r. Bu \u00e7al\u0131\u015fman\u0131n amac\u0131, moksifloksasin tedavisi alan hastalarda hiponatremi geli\u015fme s\u0131kl\u0131\u011f\u0131n\u0131 ara\u015ft\u0131rmak ve moksifloksasinin hiponatremi d\u00fczeylerine inmemi\u015f olsa bile serum sodyum d\u00fczeylerinde bir de\u011fi\u015fikli\u011fe sebep olup olmad\u0131\u011f\u0131n\u0131 incelemektir. Y\u00f6ntemler: Ara\u015ft\u0131rma grubu moksifloksasin tedavisi alm\u0131\u015f 36 hastan\u0131n dosyalar\u0131n\u0131n ve Hastane Bilgi Y\u00f6netim Sistemi verilerinin ge\u00e7mi\u015fe y\u00f6nelik olarak taranmas\u0131yla […]<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5129],"tags":[4627,4558],"class_list":["post-13967","post","type-post","status-publish","format-standard","hentry","category-ozgun-arastirma","tag-hiponatremi","tag-moksifloksasin"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts\/13967","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/comments?post=13967"}],"version-history":[{"count":0,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts\/13967\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/media?parent=13967"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/categories?post=13967"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/tags?post=13967"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}