{"id":13937,"date":"2021-01-05T01:21:44","date_gmt":"2021-01-04T22:21:44","guid":{"rendered":"https:\/\/www.klimikdergisi.org\/\/2021\/01\/05\/genislemis-spektrumlu-laktamaz-ureten-escherichia-colinin-etken-oldugu-toplum-kokenli-uriner-sistem-infeksiyonlarinda-risk-faktorlerinin-degerlendirilmesi\/"},"modified":"2021-01-05T01:21:44","modified_gmt":"2021-01-04T22:21:44","slug":"genislemis-spektrumlu-laktamaz-ureten-escherichia-colinin-etken-oldugu-toplum-kokenli-uriner-sistem-infeksiyonlarinda-risk-faktorlerinin-degerlendirilmesi","status":"publish","type":"post","link":"https:\/\/www.klimikdergisi.org\/tr\/2021\/01\/05\/genislemis-spektrumlu-laktamaz-ureten-escherichia-colinin-etken-oldugu-toplum-kokenli-uriner-sistem-infeksiyonlarinda-risk-faktorlerinin-degerlendirilmesi\/","title":{"rendered":"Geni\u015flemi\u015f Spektrumlu β-Laktamaz \u00dcreten Escherichia coli’nin Etken Oldu\u011fu Toplum K\u00f6kenli \u00dcriner Sistem \u0130nfeksiyonlar\u0131nda Risk Fakt\u00f6rlerinin De\u011ferlendirilmesi"},"content":{"rendered":"

Ama\u00e7<\/strong>: Bu \u00e7al\u0131\u015fmada geni\u015flemi\u015f spektrumlu \u03b2-laktamaz (GSBL) \u00fcreten Escherichia coli\u2019ye ba\u011fl\u0131 toplum k\u00f6kenli \u00fcriner sistem infeksiyonlar\u0131 (\u00dcS\u0130\u2019ler)\u2019nda risk fakt\u00f6rlerinin belirlenmesi ve bu k\u00f6kenlerin antibiyotiklere diren\u00e7 oranlar\u0131n\u0131n saptanmas\u0131 ama\u00e7lanm\u0131\u015ft\u0131r.<\/p>\n

Y\u00f6ntemler<\/strong>: Trakya \u00dcniversitesi Sa\u011fl\u0131k Ara\u015ft\u0131rma ve Uygulama Merkezi \u0130nfeksiyon Hastal\u0131klar\u0131 ve Klinik Mikrobiyoloji Servisi\u2019nde 1 Ocak 2008-1 Ocak 2018 tarihleri aras\u0131nda \u00dcS\u0130 tan\u0131s\u0131yla izlenen ve idrar k\u00fclt\u00fcr\u00fcnde E. coli \u00fcremesi olan hastalar retrospektif olarak incelenmi\u015ftir. \u0130drar k\u00fclt\u00fcr\u00fcnde GSBL-pozitif E. coli \u00fcreyen hastalar olgu grubunu, GSBL-negatif E. coli \u00fcreyen hastalar kontrol grubunu olu\u015fturmu\u015ftur.<\/p>\n

Bulgular<\/strong>: \u00c7al\u0131\u015fmaya 346 hastada saptanan 379 \u00dcS\u0130 ata\u011f\u0131 dahil edildi. GSBL-pozitif E. coli \u00fcremesi olan 117 (%30.9) atak olgu grubunu, GSBL-negatif E. coli \u00fcremesi olan 262 (%69.1) atak kontrol grubunu olu\u015fturdu. Tek de\u011fi\u015fkenli analizlerde gen\u00e7 ya\u015f (olgu grubunda ortalama 62\u00b119.6 y\u0131l; kontrol grubunda 68\u00b119.4 y\u0131l), bir solid organda malignite, \u00fcriner patolojiler, \u00fcriner kateterizasyon, son alt\u0131 ayda \u00fcrolojik i\u015flem \u00f6yk\u00fcs\u00fc, son \u00fc\u00e7 ayda hastanede yat\u0131\u015f \u00f6yk\u00fcs\u00fc, son \u00fc\u00e7 ayda antibiyotik kullan\u0131m\u0131 ve tekrarlayan \u00dcS\u0130, GSBL \u00fcretimi a\u00e7\u0131s\u0131ndan anlaml\u0131 bulundu (p<0.05). \u00c7ok de\u011fi\u015fkenli analizlerde bir solid organda malignite (OR: 2.267; GA: 1.205-4.266; p=0.011), \u00fcriner kateterizasyon (OR: 2.266; GA: 1.186-4.330; p=0.013), son \u00fc\u00e7 ay i\u00e7inde antibiyotik kullan\u0131m\u0131 (OR: 5.050; GA: 3.038-8.395; p=0.000) GSBL \u00fcretimi a\u00e7\u0131s\u0131ndan ba\u011f\u0131ms\u0131z risk fakt\u00f6r\u00fc olarak saptand\u0131. Olgu grubunda ampirik tedavi etkinli\u011fi daha d\u00fc\u015f\u00fck oranda saptan\u0131rken, hastanede yat\u0131\u015f s\u00fcresi daha uzun bulundu. E. coli k\u00f6kenlerinin fosfomisin ve nitrofurantoin d\u0131\u015f\u0131ndaki antibiyotiklere diren\u00e7 oranlar\u0131n\u0131n y\u00fcksek oldu\u011fu ve \u00dcS\u0130\u2019lerin ampirik tedavisinde kullan\u0131lmalar\u0131n\u0131n uygun olmad\u0131\u011f\u0131 saptand\u0131.<\/p>\n

Sonu\u00e7lar<\/strong>: Toplumdan gelen hastada GSBL \u00fcretimi a\u00e7\u0131s\u0131ndan risk fakt\u00f6rlerinin ve antibiyotik diren\u00e7 oranlar\u0131n\u0131n bilinmesi, hem \u00dcS\u0130\u2019lerin ampirik tedavi ba\u015far\u0131s\u0131n\u0131 art\u0131racak, hem de gereksiz antibiyotik kullan\u0131m\u0131n\u0131 azaltacakt\u0131r.<\/p>\n

Klimik Dergisi 2020; 33(1): 55-61.<\/p>\n

Cite this article as<\/strong>: Kara M, Elmaslar-Mert HT, Kulo\u011flu F, Akata F. [Evaluation of risk factors in community acquired urinary tract infections caused by extended spectrum \u03b2-lactamase-producing Escherichia coli]. Klimik Derg. 2020; 33(1): 55-61. Turkish.<\/p>\n","protected":false},"excerpt":{"rendered":"

Ama\u00e7: Bu \u00e7al\u0131\u015fmada geni\u015flemi\u015f spektrumlu \u03b2-laktamaz (GSBL) \u00fcreten Escherichia coli\u2019ye ba\u011fl\u0131 toplum k\u00f6kenli \u00fcriner sistem infeksiyonlar\u0131 (\u00dcS\u0130\u2019ler)\u2019nda risk fakt\u00f6rlerinin belirlenmesi ve bu k\u00f6kenlerin antibiyotiklere diren\u00e7 oranlar\u0131n\u0131n saptanmas\u0131 ama\u00e7lanm\u0131\u015ft\u0131r. Y\u00f6ntemler: Trakya \u00dcniversitesi Sa\u011fl\u0131k Ara\u015ft\u0131rma ve Uygulama Merkezi \u0130nfeksiyon Hastal\u0131klar\u0131 ve Klinik Mikrobiyoloji Servisi\u2019nde 1 Ocak 2008-1 Ocak 2018 tarihleri aras\u0131nda \u00dcS\u0130 tan\u0131s\u0131yla izlenen ve idrar k\u00fclt\u00fcr\u00fcnde […]<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5129],"tags":[3191,4355,3474,3465],"class_list":["post-13937","post","type-post","status-publish","format-standard","hentry","category-ozgun-arastirma","tag-escherichia-coli","tag-genislemis-spektrumlu-laktamazlar","tag-risk-faktorleri","tag-uriner-sistem-infeksiyonlari"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts\/13937","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/comments?post=13937"}],"version-history":[{"count":0,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts\/13937\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/media?parent=13937"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/categories?post=13937"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/tags?post=13937"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}