{"id":13811,"date":"2021-01-05T01:21:36","date_gmt":"2021-01-04T22:21:36","guid":{"rendered":"https:\/\/www.klimikdergisi.org\/\/2021\/01\/05\/toplum-kokenli-uriner-sistem-infeksiyonlarinda-genislemis-spektrumlu-laktamaz-ureten-escherichia-coli-ve-klebsiella-spp-ve-antimikrobiyal-direncleri\/"},"modified":"2021-01-05T01:21:36","modified_gmt":"2021-01-04T22:21:36","slug":"toplum-kokenli-uriner-sistem-infeksiyonlarinda-genislemis-spektrumlu-laktamaz-ureten-escherichia-coli-ve-klebsiella-spp-ve-antimikrobiyal-direncleri","status":"publish","type":"post","link":"https:\/\/www.klimikdergisi.org\/tr\/2021\/01\/05\/toplum-kokenli-uriner-sistem-infeksiyonlarinda-genislemis-spektrumlu-laktamaz-ureten-escherichia-coli-ve-klebsiella-spp-ve-antimikrobiyal-direncleri\/","title":{"rendered":"Toplum K\u00f6kenli \u00dcriner Sistem \u0130nfeksiyonlar\u0131nda Geni\u015flemi\u015f Spektrumlu β-Laktamaz \u00dcreten Escherichia coli ve Klebsiella spp. ve Antimikrobiyal Diren\u00e7leri"},"content":{"rendered":"

Ama\u00e7<\/strong>: Geni\u015flemi\u015f spektrumlu \u03b2-laktamaz (GSBL) \u00fcretimi, Gram-negatif patojenlerde g\u00f6r\u00fclen en \u00f6nemli antimikrobiyal diren\u00e7 mekanizmas\u0131d\u0131r. Bu \u00e7al\u0131\u015fmada, toplum k\u00f6kenli \u00fcriner sistem infeksiyonlar\u0131 (\u00dcS\u0130\u2019ler)\u2019ndan izole edilen Escherichia coli ve Klebsiella spp. t\u00fcrlerinde GSBL \u00fcretim s\u0131kl\u0131\u011f\u0131 ve antibiyotik diren\u00e7 oranlar\u0131n\u0131n ara\u015ft\u0131r\u0131lmas\u0131 ama\u00e7lanm\u0131\u015ft\u0131r.<\/p>\n

Y\u00f6ntemler<\/strong>: Bu geriye d\u00f6n\u00fck kesitsel ara\u015ft\u0131rmada, toplum k\u00f6kenli \u00dcS\u0130 tan\u0131s\u0131 konulan 520 hastan\u0131n idrar k\u00fclt\u00fcr\u00fcnde \u00fcreyen E. coli ve Klebsiella spp. izolatlar\u0131na ait GSBL \u00fcretimi ve antimikrobiyal duyarl\u0131l\u0131k test sonu\u00e7lar\u0131 saptanm\u0131\u015f ve su\u015flar\u0131n GSBL \u00fcreticisi olup olmama durumuna g\u00f6re antibiyotik diren\u00e7 s\u0131kl\u0131klar\u0131ndaki de\u011fi\u015fimler kar\u015f\u0131la\u015ft\u0131r\u0131lm\u0131\u015ft\u0131r.<\/p>\n

Bulgular<\/strong>: Toplam 220 hastada E. coli ve 38 hastada Klebsiella spp. \u00fcremi\u015ftir. \u0130zolatlar\u0131n GSBL olu\u015fturma s\u0131kl\u0131\u011f\u0131 s\u0131ras\u0131yla %40 ve %47.4, karbapenem direnci oran\u0131 ise %3.1 olarak bulunmu\u015ftur. \u0130zolatlar\u0131n en fazla diren\u00e7li oldu\u011fu antibiyotikler amoksisilin-klavulanat (%46), siprofloksasin (%44.9) ve seftriakson (%42.2) olarak; en az diren\u00e7li olduklar\u0131 ila\u00e7lar ise kolistin (%0.3), fosfomisin (%1.5), amikasin (%3.1) ve nitrofurantoin (%4.2) olarak saptanm\u0131\u015ft\u0131r. GSBL \u00fcreten su\u015flarda, kolistin, nitrofurantoin ve fosfomisin d\u0131\u015f\u0131nda ara\u015ft\u0131r\u0131lan t\u00fcm antibiyotiklere istatistiksel olarak anlaml\u0131 olmak \u00fczere daha y\u00fcksek diren\u00e7 bulunmu\u015ftur.<\/p>\n

Sonu\u00e7lar<\/strong>: Bu \u00e7al\u0131\u015fmada, toplum k\u00f6kenli izolatlar\u0131n neredeyse yar\u0131s\u0131n\u0131n GSBL \u00fcreticisi oldu\u011fu ve bu su\u015flar\u0131n karbapenemler ve kolistin gibi son se\u00e7enek antibiyotikler de dahil olmak \u00fczere bir\u00e7ok antibiyoti\u011fe kar\u015f\u0131 diren\u00e7 kazand\u0131\u011f\u0131 g\u00f6sterilmi\u015ftir. E. coli ve Klebsiella spp. gibi toplum k\u00f6kenli \u00dcS\u0130\u2019lerdeki en s\u0131k patojenlerin antimikrobiyal diren\u00e7 oranlar\u0131n\u0131n art\u0131\u015f\u0131n\u0131 engellemek i\u00e7in tedavilerinin m\u00fcmk\u00fcn oldu\u011funca duyarl\u0131l\u0131k testi sonu\u00e7lar\u0131na g\u00f6re planlanmas\u0131 gerekmektedir.<\/p>\n

Klimik Dergisi. 2020; 33(2): 163-8.<\/p>\n

Cite this article as<\/strong>: \u015eenol A, Yakupo\u011fullar\u0131 Y, \u015eenol FF. [Extended-spectrum \u03b2-lactamase-producing Escherichia coli and Klebsiella spp. in community-acquired urinary tract infections and their antimicrobial resistance]. Klimik Derg. 2020; 33(2): 163-8. Turkish.<\/p>\n","protected":false},"excerpt":{"rendered":"

Ama\u00e7: Geni\u015flemi\u015f spektrumlu \u03b2-laktamaz (GSBL) \u00fcretimi, Gram-negatif patojenlerde g\u00f6r\u00fclen en \u00f6nemli antimikrobiyal diren\u00e7 mekanizmas\u0131d\u0131r. Bu \u00e7al\u0131\u015fmada, toplum k\u00f6kenli \u00fcriner sistem infeksiyonlar\u0131 (\u00dcS\u0130\u2019ler)\u2019ndan izole edilen Escherichia coli ve Klebsiella spp. t\u00fcrlerinde GSBL \u00fcretim s\u0131kl\u0131\u011f\u0131 ve antibiyotik diren\u00e7 oranlar\u0131n\u0131n ara\u015ft\u0131r\u0131lmas\u0131 ama\u00e7lanm\u0131\u015ft\u0131r. Y\u00f6ntemler: Bu geriye d\u00f6n\u00fck kesitsel ara\u015ft\u0131rmada, toplum k\u00f6kenli \u00dcS\u0130 tan\u0131s\u0131 konulan 520 hastan\u0131n idrar k\u00fclt\u00fcr\u00fcnde \u00fcreyen […]<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5129],"tags":[3191,4355,5042,3465],"class_list":["post-13811","post","type-post","status-publish","format-standard","hentry","category-ozgun-arastirma","tag-escherichia-coli","tag-genislemis-spektrumlu-laktamazlar","tag-klebsiella-spp","tag-uriner-sistem-infeksiyonlari"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts\/13811","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/comments?post=13811"}],"version-history":[{"count":0,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts\/13811\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/media?parent=13811"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/categories?post=13811"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/tags?post=13811"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}