{"id":13667,"date":"2021-01-05T01:21:24","date_gmt":"2021-01-04T22:21:24","guid":{"rendered":"https:\/\/www.klimikdergisi.org\/\/2021\/01\/05\/hepatit-b-virusuyla-iliskili-sirozu-olan-hastalarda-entekavir-ve-tenofovir-tedavisi-iki-yillik-tedavi-sonuclarinin-karsilastirilmasi\/"},"modified":"2021-01-05T07:26:17","modified_gmt":"2021-01-05T04:26:17","slug":"hepatit-b-virusuyla-iliskili-sirozu-olan-hastalarda-entekavir-ve-tenofovir-tedavisi-iki-yillik-tedavi-sonuclarinin-karsilastirilmasi","status":"publish","type":"post","link":"https:\/\/www.klimikdergisi.org\/tr\/2021\/01\/05\/hepatit-b-virusuyla-iliskili-sirozu-olan-hastalarda-entekavir-ve-tenofovir-tedavisi-iki-yillik-tedavi-sonuclarinin-karsilastirilmasi\/","title":{"rendered":"Hepatit B Virusuyla \u0130li\u015fkili Sirozu Olan Hastalarda Entekavir ve Tenofovir Tedavisi: \u0130ki Y\u0131ll\u0131k Tedavi Sonu\u00e7lar\u0131n\u0131n Kar\u015f\u0131la\u015ft\u0131r\u0131lmas\u0131"},"content":{"rendered":"<p><strong>Ama\u00e7<\/strong>: Hepatit B virusu (HBV) infeksiyonu siroz ve hepatosel\u00fcler kanserin en s\u0131k nedenlerinden biridir. Tedavide interferonlar ve n\u00fckleoz(t)id analoglar\u0131 kullan\u0131lmakta olup, entekavir (ETV) ve tenofovir disoproksil fumarat (TDF) en g\u00fc\u00e7l\u00fc oral antivirallerdir. Bu \u00e7al\u0131\u015fmada hepatit B\u2019ye ba\u011fl\u0131 sirozu olan ve daha \u00f6nce antiviral tedavi almam\u0131\u015f (naif) hastalarda ETV veya TDF tedavilerinin etkinli\u011fi ve g\u00fcvenilirli\u011fi ara\u015ft\u0131r\u0131lm\u0131\u015ft\u0131r.<\/p>\n<p><strong>Y\u00f6ntemler<\/strong>: \u00c7al\u0131\u015fmaya kronik HBV infeksiyonuna ba\u011fl\u0131 karaci\u011fer sirozu olan, tedavi-naif olup ilk tedavi rejimi olarak ETV veya TDF ba\u015flanm\u0131\u015f olan toplam 58 hasta dahil edildi. Hastalar\u0131n cinsiyet, ya\u015f, Child-Pugh ve \u201cmodel for end-stage liver disease\u201d (MELD) skorlar\u0131 gibi demografik \u00f6zelliklerinin yan\u0131 s\u0131ra bazal ve tedavinin 3, 6, 12, 18 ve 24. aylar\u0131ndaki HBV DNA, HBsAg, HBeAg, serum alanin aminotransferaz, kreatinin, fosfor ve total kreatin kinaz seviyeleri kaydedildi. Takip periyodundaki ila\u00e7 yan etkileri ve siroz komplikasyonlar\u0131 da belirlendi. ETV ve TDF gruplar\u0131 tedavi yan\u0131tlar\u0131 a\u00e7\u0131s\u0131ndan kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131.<\/p>\n<p><strong>Bulgular<\/strong>: TDF ve ETV gruplar\u0131nda s\u0131ras\u0131yla 32 ve 26 hasta yer ald\u0131. Her iki grupta hastalar\u0131n \u00e7o\u011funlu\u011fu Child-Pugh s\u0131n\u0131f A\u2019yd\u0131. Cinsiyet ve ya\u015fa g\u00f6re da\u011f\u0131l\u0131m ve bazal laboratuvar parametreleri her iki grupta da benzerdi (p&gt;0.05). HBV DNA\u2019lar\u0131 negatifle\u015fen hastalar\u0131n y\u00fczdesi, sadece tedavinin alt\u0131nc\u0131 ay\u0131ndaki ETV grubunda anlaml\u0131 olarak daha fazla iken (p=0.04), 12., 18. ve 24. aylarda gruplar aras\u0131nda istatistiksel olarak anlaml\u0131 farklar yoktu. Takip s\u00fcresi sonunda (24. ayda) TDF grubundaki hastalar\u0131n %100\u2019\u00fcnde, ETV grubundakilerin ise %89\u2019unda HBV DNA negatifti (p=0.31). Takip s\u00fcrecinde her iki grupta da serum kreatinin seviyelerinde anlaml\u0131 art\u0131\u015flar oldu\u011fu g\u00f6zlendiyse (p=0.04) de de\u011ferler normal s\u0131n\u0131rlar i\u00e7erisinde kalmaktayd\u0131 ve gruplar aras\u0131nda istatistiksel olarak anlaml\u0131 bir fark yoktu (p=0.71). Tedavi sonunda TDF grubunda ortalama MELD ve Child-Pugh skorlar\u0131nda anlaml\u0131 azalmalar oldu\u011fu g\u00f6zlendi (s\u0131ras\u0131yla p=0.02 ve p=0.001). ETV grubunda ise ortalama Child-Pugh skorunda anlaml\u0131 azalma varken, MELD skorunda anlaml\u0131 bir de\u011fi\u015fiklik g\u00f6zlenmedi (s\u0131ras\u0131yla p=0.003 ve p=0.14).<\/p>\n<p><strong>Sonu\u00e7lar<\/strong>: ETV ve TDF, HBV-pozitif sirozu olan daha \u00f6nce tedavi almam\u0131\u015f hastalarda olduk\u00e7a g\u00fcvenli ve etkindir. Her iki ilac\u0131n etkinli\u011finin benzer oldu\u011fu bulunmu\u015ftur.<\/p>\n<p>Klimik Dergisi 2020; 33(3): X.<\/p>\n<p><strong>Cite this article as<\/strong>: Alkan E, Ak\u0131n M, Tuna Y. [Entecavir and tenofovir treatment in patients with hepatitis B virus-related cirrhosis: A comparison of results of two-year treatment]. Klimik Derg. 2020; 33(3): 264-9. Turkish.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ama\u00e7: Hepatit B virusu (HBV) infeksiyonu siroz ve hepatosel\u00fcler kanserin en s\u0131k nedenlerinden biridir. Tedavide interferonlar ve n\u00fckleoz(t)id analoglar\u0131 kullan\u0131lmakta olup, entekavir (ETV) ve tenofovir disoproksil fumarat (TDF) en g\u00fc\u00e7l\u00fc oral antivirallerdir. Bu \u00e7al\u0131\u015fmada hepatit B\u2019ye ba\u011fl\u0131 sirozu olan ve daha \u00f6nce antiviral tedavi almam\u0131\u015f (naif) hastalarda ETV veya TDF tedavilerinin etkinli\u011fi ve g\u00fcvenilirli\u011fi ara\u015ft\u0131r\u0131lm\u0131\u015ft\u0131r. [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":21732,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5129],"tags":[4964,3328,3540,5164],"class_list":["post-13667","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ozgun-arastirma","tag-entekavir","tag-kronik-hepatit-b","tag-siroz","tag-tenofovir-2"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts\/13667","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/comments?post=13667"}],"version-history":[{"count":1,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts\/13667\/revisions"}],"predecessor-version":[{"id":21752,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts\/13667\/revisions\/21752"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/media\/21732"}],"wp:attachment":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/media?parent=13667"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/categories?post=13667"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/tags?post=13667"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}