{"id":13637,"date":"2021-01-05T01:21:22","date_gmt":"2021-01-04T22:21:22","guid":{"rendered":"https:\/\/www.klimikdergisi.org\/\/2021\/01\/05\/covid-19-tedavisinde-favipiravir-ve-hidroksiklorokinin-karaciger-guvenliginin-karsilastirilmasi\/"},"modified":"2021-01-05T01:21:22","modified_gmt":"2021-01-04T22:21:22","slug":"covid-19-tedavisinde-favipiravir-ve-hidroksiklorokinin-karaciger-guvenliginin-karsilastirilmasi","status":"publish","type":"post","link":"https:\/\/www.klimikdergisi.org\/tr\/2021\/01\/05\/covid-19-tedavisinde-favipiravir-ve-hidroksiklorokinin-karaciger-guvenliginin-karsilastirilmasi\/","title":{"rendered":"COVID-19 Tedavisinde Favipiravir ve Hidroksiklorokinin Karaci\u011fer G\u00fcvenli\u011finin Kar\u015f\u0131la\u015ft\u0131r\u0131lmas\u0131"},"content":{"rendered":"<p><strong>Ama\u00e7<\/strong>: Aral\u0131k 2019&#39;da \u00c7in&#39;in Vuhan kentinde ortaya \u00e7\u0131kan ilk vakadan bu yana, COVID-19 t\u00fcm d\u00fcnyaya yay\u0131ld\u0131 ve 30 Ocak 2020&#39;de D\u00fcnya Sa\u011fl\u0131k \u00d6rg\u00fct\u00fc taraf\u0131ndan pandemi olarak ilan edildi. COVID-19\u2019u tedavi etmek veya \u00f6nlemek i\u00e7in spesifik bir antiviral ila\u00e7 ya da a\u015f\u0131 olmamakla birlikte; favipiravir, hidroksiklorokin ve kombinasyonlar\u0131 \u00fclkemizde COVID-19 tedavisinde kullan\u0131lmaktad\u0131r. Bu \u00e7al\u0131\u015fmada COVID-19 tan\u0131s\u0131yla takip etti\u011fimiz hastalar\u0131n demografik, klinik ve laboratuvar bulgular\u0131, verilen tedavilerin ve bunlar\u0131n \u00f6zellikle karaci\u011fer testleri \u00fczerine etkilerinin de\u011ferlendirilmesi ama\u00e7lanm\u0131\u015ft\u0131r.<\/p>\n<p><strong>Y\u00f6ntemler<\/strong>: Bu \u00e7al\u0131\u015fma retrospektif olarak tasarland\u0131 ve Erciyes \u00dcniversitesi T\u0131p Fak\u00fcltesi \u0130nfeksiyon Hastal\u0131klar\u0131 ve Klinik Mikrobiyoloji Anabilim Dal\u0131&#39;nda 3 Nisan 2020-28 Eyl\u00fcl 2020 tarihleri aras\u0131nda T.C. Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131 K\u0131lavuzlar\u0131na g\u00f6re \u201ckesin vaka\u201d kriterlerini kar\u015f\u0131layan COVID-19 hastalar\u0131 \u00e7al\u0131\u015fmaya al\u0131nd\u0131. Ya\u015f, cinsiyet, hastanede kal\u0131\u015f s\u00fcresi, komorbiditeler, maligniteler, semptomlar, hastal\u0131k \u015fiddeti, kullan\u0131lan antibiyotikler ve di\u011fer ila\u00e7lar, laboratuvar ve toraks bilgisayarl\u0131 tomografi bulgular\u0131, mortalite oranlar\u0131 kaydedildi. Hastalar hidroksiklorokin ve favipiravir grubu olarak ikiye ayr\u0131ld\u0131. Gruplar demografik veriler, klinik bulgular, tedavi protokolleri ve laboratuvar bulgular\u0131 (\u00f6zellikle karaci\u011fer testleri) a\u00e7\u0131s\u0131ndan de\u011ferlendirildi. Karaci\u011fer testlerinin sonu\u00e7lar\u0131 tedavinin 0., 3. ve 5. g\u00fcnlerinde ve tedavi bitiminden 48-72 saat sonra kaydedildi.<\/p>\n<p><strong>Bulgular<\/strong>: \u00c7al\u0131\u015fmaya hidroksiklorokin grubunda 20 ve favipiravir grubunda 32 olmak \u00fczere COVID-19 tan\u0131s\u0131 konulmu\u015f toplam 52 hasta al\u0131nd\u0131. Genel olarak, iki grup aras\u0131nda hastalar\u0131n temel \u00f6zellikleri bak\u0131m\u0131ndan anlaml\u0131 bir fark g\u00f6zlemlenmedi. Hidroksiklorokin grubunda aspartat aminotransferaz, alanin aminotransferaz (ALT), total bilir\u00fcbin, direkt bilir\u00fcbin, laktat dehidrogenez (LDH), \u03b3-glutamil transferaz (GGT) ve alkalen fosfataz de\u011ferlerinin hi\u00e7birinde istatistiksel olarak anlaml\u0131 bir art\u0131\u015f saptanmad\u0131. Favipiravir grubunda ise, ALT (p&lt;0.0001), LDH (p=0.01) ve GGT (p&lt;0.0001) de\u011ferlerinde anlaml\u0131 art\u0131\u015flar oldu\u011fu bulundu.<\/p>\n<p><strong>Sonu\u00e7lar<\/strong>: Favipiravirin COVID-19 tedavisinde kesin etkinli\u011fini ispatlayacak ba\u015fka klinik \u00e7al\u0131\u015fmalara gereksinim duyulmas\u0131n\u0131n yan\u0131 s\u0131ra favipiravire ba\u011fl\u0131 karaci\u011fer hasar\u0131n\u0131n da tedavi s\u0131ras\u0131nda g\u00f6z ard\u0131 edilmemesi gereken \u00f6nemli bir durum oldu\u011fu kan\u0131s\u0131nday\u0131z.\u00a0<\/p>\n<p>Klimik Dergisi 2020; 33(3): 235-40.<\/p>\n<p><strong>Cite this article as<\/strong>: \u0130zci-\u00c7etinkaya F, Karag\u00f6z H, Y\u0131ld\u0131z O. [Comparison of liver safety of favipiravir and hydroxychloroquine in COVID-19 treatment]. Klimik Derg. 2020; 33(3): 235-40. Turkish.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ama\u00e7: Aral\u0131k 2019&#39;da \u00c7in&#39;in Vuhan kentinde ortaya \u00e7\u0131kan ilk vakadan bu yana, COVID-19 t\u00fcm d\u00fcnyaya yay\u0131ld\u0131 ve 30 Ocak 2020&#39;de D\u00fcnya Sa\u011fl\u0131k \u00d6rg\u00fct\u00fc taraf\u0131ndan pandemi olarak ilan edildi. COVID-19\u2019u tedavi etmek veya \u00f6nlemek i\u00e7in spesifik bir antiviral ila\u00e7 ya da a\u015f\u0131 olmamakla birlikte; favipiravir, hidroksiklorokin ve kombinasyonlar\u0131 \u00fclkemizde COVID-19 tedavisinde kullan\u0131lmaktad\u0131r. Bu \u00e7al\u0131\u015fmada COVID-19 tan\u0131s\u0131yla [&hellip;]<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5129],"tags":[5019,5115,5116,5118],"class_list":["post-13637","post","type-post","status-publish","format-standard","hentry","category-ozgun-arastirma","tag-covid19","tag-favipiravir","tag-hidroksiklorokin","tag-karaciger-testleri"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts\/13637","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/comments?post=13637"}],"version-history":[{"count":0,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/posts\/13637\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/media?parent=13637"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/categories?post=13637"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/tr\/wp-json\/wp\/v2\/tags?post=13637"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}