{"id":15534,"date":"2021-01-05T01:23:52","date_gmt":"2021-01-04T22:23:52","guid":{"rendered":"https:\/\/www.klimikdergisi.org\/\/2021\/01\/05\/the-relationship-between-the-opportunistic-diseases-and-viral-load-and-cd4-t-cell-count-in-patients-with-hiv-infection\/"},"modified":"2021-01-05T01:23:52","modified_gmt":"2021-01-04T22:23:52","slug":"the-relationship-between-the-opportunistic-diseases-and-viral-load-and-cd4-t-cell-count-in-patients-with-hiv-infection","status":"publish","type":"post","link":"https:\/\/www.klimikdergisi.org\/en\/2021\/01\/05\/the-relationship-between-the-opportunistic-diseases-and-viral-load-and-cd4-t-cell-count-in-patients-with-hiv-infection\/","title":{"rendered":"The Relationship Between the Opportunistic Diseases and Viral Load and CD4+ T Cell Count in Patients With HIV Infection"},"content":{"rendered":"<h1>Abstract<\/h1>\n<p> <strong>Objective<\/strong>: This study was planned to determine opportunis\u00adtic diseases (ODs)\u00a0 among individuals infected with human immunodeficiency virus (HIV) and whether there were any relationship between ODs, CD4+ T cells and the HIV viral load in Turkey.<\/p>\n<p> <strong>Methods<\/strong>: In the present study, HIV-infected individuals followed by Istanbul Education and Research Hospital between January 2002 and April 2012 were evaluated retrospectively. Demographics, CD4+ T cell count at the time of OD development, HIV RNA level, and treatment status of the patients were determined.<\/p>\n<p> <strong>Results<\/strong>: In 61 (28.8%) of 212 cases included in the study, 89 ODs occurred. Mean (\u00b1standard deviation) CD4+ T lymphocyte count was 169.6 (\u00b123.0)\/mm3, and logHIV RNA level was 5.1 (\u00b11.4) at the time of OD development. The most commonly encountered ODs were oral candidiasis, tuberculosis and herpes zoster. There was statistically significant relationship between number of ODs and CD4+ T lymphocyte count and HIV RNA levels. Fatal diseases like Toxoplasma encephalitis, HIV encephalopathy and cytomegalovirus infection occurred more frequently when CD4+ T cell count was below 50 cells\/mm3 and the viral load was high (&gt;5 log). ODs were more frequently seen in cases with high viral load when the number of CD4+ T cell count was below 200\/mm3. If viral load was over 5 log and the number of CD4+ T cells was low, the number of ODs was higher.<\/p>\n<p> <strong>Conclusions<\/strong>: Oral candidiasis, tuberculosis, and herpes zoster have been the most commonly encountered ODs in Turkey. ODs occur more frequently in patients with low CD4+ T cell counts and high viral loads.<span lang=\"EN-US\" ms=\"\" mso-fareast-font-family:=\"\" new=\"\" times=\"\">\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Abstract Objective: This study was planned to determine opportunis\u00adtic diseases (ODs)\u00a0 among individuals infected with human immunodeficiency virus (HIV) and whether there were any relationship between ODs, CD4+ T cells and the HIV viral load in Turkey. Methods: In the present study, HIV-infected individuals followed by Istanbul Education and Research Hospital between January 2002 and [&hellip;]<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5130],"tags":[4443,3228,4441,4232],"class_list":["post-15534","post","type-post","status-publish","format-standard","hentry","category-original-article","tag-cd4-t-cell-count","tag-hiv","tag-immune-system","tag-opportunistic-infections"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.klimikdergisi.org\/en\/wp-json\/wp\/v2\/posts\/15534","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.klimikdergisi.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.klimikdergisi.org\/en\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/en\/wp-json\/wp\/v2\/comments?post=15534"}],"version-history":[{"count":0,"href":"https:\/\/www.klimikdergisi.org\/en\/wp-json\/wp\/v2\/posts\/15534\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.klimikdergisi.org\/en\/wp-json\/wp\/v2\/media?parent=15534"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/en\/wp-json\/wp\/v2\/categories?post=15534"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.klimikdergisi.org\/en\/wp-json\/wp\/v2\/tags?post=15534"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}